人工软骨支架材料、结构设计与制备技术研究进展  

Research progress on materials,structure and preparation technology ofarticular cartilage scaffolds

作　　者：刘天 王臻[3] 储彬[3] 陈昌盛[3] 赵小文 邢璐 左佳盛 王松[3] 刘伟强 LIU Tian;WANG Zhen;CHU Bin;CHEN Changsheng;ZHAO Xiaowen;XING Lu;ZUO Jiasheng;WANG Song;LIU Weiqiang(Tsinghua Shenzhen International Graduate School,Tsinghua University,Shenzhen 518055,China;Department of Mechanical Engineering,Tsinghua University,Beijing 100084,China;Biomechanics and Biotechnology Lab,Research Institute of Tsinghua University in Shenzhen,Shenzhen 518057,China;Shenzhen Excellent Technology Co.,Ltd.,Shenzhen 518054,China)

机构地区：[1]清华大学深圳国际研究生院,深圳518055 [2]清华大学机械工程系,北京100084 [3]深圳清华大学研究院、生物医用材料及植入器械实验室,深圳518057 [4]深圳市艾科赛龙科技股份有限公司,深圳518054

出　　处：《功能材料》2023年第3期3001-3011,共11页Journal of Functional Materials

基　　金：广东省自然科学基金(2020B1515120082);深圳市自然科学基金(JCYJ20190807144001746,JCYJ20210324100601005,2021Szvup098,JCYJ20200109150605937,JSGG20191129114422849)。

摘　　要：骨软骨是一种半透明状组织,主要功能是传递、吸收应力和减少摩擦。由于结构和功能复杂性,软骨一旦受损很难修复和再生,软骨缺损治疗仍是一大临床难题。随着再生医学蓬勃发展,组织工程人工软骨技术有望在软骨修复和治疗领域发挥重要作用。首先介绍了天然关节软骨不同分层的解剖结构和功能特征,然后重点从人工软骨支架构建材料、结构设计和制备技术等方面系统地综述了人工软骨组织工程技术的最新进展,最后讨论了人工软骨支架当前面临主要问题和未来发展方向,以期为相关研究提供参考。Cartilage is a kind of translucent tissue whose main function is to transmit and absorb stress as well as reduce friction.Due to the complexity of structure and function,damaged cartilage is difficult to repair and regenerate.The treatment of cartilage defect is still a major clinical problem.With the vigorous development of regenerative medicine,tissue engineering artificial cartilage technology is expected to play an important role in the field of cartilage repair and treatment.In this review,the anatomical structure and functional characteristics of different layers of natural articular cartilage have been firstly introduced.Then,the latest progress of artificial cartilage tissue engineering technology has been summarized from the aspects of artificial cartilage scaffold construction materials,structural design and preparation technology.Finally,the main problems and future development directions of artificial cartilage scaffolds have been discussed.This review may provide reference for relevant research in the future.

关 键 词：人工软骨 支架材料 结构设计 制备技术 

分 类 号：TB303[一般工业技术—材料科学与工程]