氮杂环卡宾-铜配合物在有机催化反应中的应用研究进展  

Research progress on application of N-heterocyclic carbene-copper complexes in organocatalytic reactions

作　　者：杨秀芳[1] 张晨阳 张金[1] 王沁欢 王一涵 李泽剑 马思悦 YANG Xiu-fang;ZHANG Chen-yang;ZHANG Jin;WANG Qin-huan;WANG Yi-han;LI Ze-jian;MA Si-yue(College of Chemistry and Chemical Engineering,Shaanxi University of Science&Technology,Xi′an 710021,China;Xi′an Keyuan Municipal Engineering Consulting Co.,Ltd.,Xi′an 710000,China;College of Emergency and Trauma,Key Laboratory of Emergency and Trauma,Ministry of Education,Hainan Medical University,Haikou 571199,China)

机构地区：[1]陕西科技大学化学与化工学院,陕西西安710021 [2]西安科源市政工程咨询有限公司,陕西西安710000 [3]海南医学院急诊创伤学院急救与创伤研究教育部重点实验室,海南海口571199

出　　处：《陕西科技大学学报》2023年第2期103-114,共12页Journal of Shaanxi University of Science & Technology

基　　金：国家自然科学基金项目(22179075);陕西省科技厅重点研发计划项目(2022GY-203);陕西省教育厅专项科研计划项目(21JK0545);陕西省西安市科协青年人才托举计划项目(095920211319);海南医学院急诊创伤学院急救与创伤研究教育部重点实验室开放基金项目(KLET-202010)。

摘　　要：有机金属催化剂能让化学反应实现高选择性、高产率,并且反应条件温和、操作简单方便.其中,氮杂环卡宾(N-heterocyclic carbenes, NHCs)是一类稳定性强、价格低廉、毒性较低、易制备的配体.因为氮杂环卡宾与过渡金属具有强配位能力,使得其作为过渡金属配合物的新型配体而得到了迅速发展.相比其他金属来说,金属Cu以其价廉和储量丰富等优势而在众多金属中脱颖而出.基于此,本文以氮杂环卡宾-铜配合物(NHC-Cu)为例,总结和归纳了近十年来NHC-Cu作为催化剂在有机反应中的研究进展,主要包含Click反应(叠氮与炔环加成反应)、末端炔烃与三氟甲基酮的加成反应、共轭加成反应、羰基化反应、不对称烯丙基取代反应、A^(3)偶联反应、硼化反应和氧化反应等.Organometallic catalyst can make chemical reaction achieve high selectivity,high yield,mild reaction conditions,simple and convenient operation.Among them,N-heterocyclic carbenes(NHCs)is a kind of ligand with strong stability,low price,low toxicity and easy preparation.The strong coordination ability of nitroheterocyclic carbens with transition metals has led to its rapid development as a new ligand of transition metal complexes.Compared with other metals,metal Cu stands out among many metals due to its advantages of low price and abundant reserves.Taking nitrogen heterocyclic carben-copper complex(NHC-Cu)as an example,this paper summarized and summarized the research progress of NHC-Cu as catalyst in organic reaction in recent ten years.It mainly includes Click reaction(azide and alkyne cycloaddition reaction),addition of terminal alkynes to trifluoromethyl ketone,conjugate addition reaction,carbonylation,asymmetric allyl substitution,A^(3) coupling reaction,boriding and oxidation reaction,etc.

关 键 词：氮杂环卡宾 氮杂环卡宾-铜配合物 有机催化 

分 类 号：O626[理学—有机化学]