NAD^(+)在硫芥导致中毒损伤中的作用及研究进展  

Research progress of the role of NAD^(+)in sulfur mustard poisoning

作　　者：高一灵 于卫华 彭洁 刘瑞 吴昊 刘江正 孔德钦 GAO Yiling;YU Weihua;PENG Jie;LIU Rui;WU Hao;LIU Jiangzheng;KONG Deqin(Cadet Brigade,School of Basic Medical Sciences,Air Force Medical University;Department of Military Toxicology and Chemical Medicine,Shaanxi Provincial Key Laboratory of Free Radical Biology and Medicine,Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment,School of Military Preventive Medicine,Air Force Medical University,Xi'an 710032,China)

机构地区：[1]空军军医大学基础医学院学员大队 [2]空军军医大学军事预防医学系军事毒理学与防化医学教研室,陕西省自由基生物学重点实验室,特殊作业环境危害评估与防治教育部重点实验室,陕西西安710032

出　　处：《空军军医大学学报》2023年第3期269-274,共6页Journal of Air Force Medical University

基　　金：国家自然科学基金(NSFC-32100996);陕西省自然科学基础研究计划青年项目(2021JQ-343)。

摘　　要：硫芥(SM)作为一种经典的糜烂性化学毒剂,曾造成大量人员伤亡,目前仍有潜在威胁。SM可导致皮肤、眼睛和呼吸系统等多脏器和系统的损伤,其中毒机制不清,尚无特效救治药物。本文回顾了近年关于烟酰胺腺嘌呤二核苷酸(NAD^(+))与SM中毒方面的研究进展,介绍了NAD^(+)在体内的合成及生物学作用,阐述了SM导致细胞内NAD^(+)降低的现象及机制,重点从多聚ADP核糖聚合酶1的过度活化、沉默信息调节因子1的抑制和诱导氧化应激三个方面解析了NAD^(+)在SM导致毒性损伤中的作用,并总结了NAD^(+)前体药物治疗SM中毒的研究进展,以期为SM导致中毒损伤的机制及救治药物的研发提供新的思路。Sulfur mustard(SM),as a classic erosive chemical agent,has caused a large number of casualties and is still a potential threat.SM can cause damage to multiple organs and systems such as skin,eyes,and respiratory system.The mechanism of SM poisoning is unclear,and there is no specific treatment drug.This paper reviews the recent research progress on nicotinamide adenine dinucleotide(NAD^(+))and SM poisoning,introduces the synthesis and biological function of NAD^(+)in vivo,and elucidates the phenomenon and mechanism behind SM-induced reduction of NAD^(+)in cells.In particular,the role of NAD^(+)in SM-induced toxic injury is analyzed from three aspects:overactivation of poly(ADP-ribose)polymerase 1,inhibition of silent information regulator 1,and induction of oxidative stress.Moreover,the research progress of NAD^(+)precursor drugs in the treatment of SM poisoning is discussed,aiming at providing new ideas for the mechanism of SM poisoning and the development of therapeutic drugs.

关 键 词：硫芥 烟酰胺腺嘌呤二核苷酸 多聚ADP核糖聚合酶1 沉默信息调节因子1 

分 类 号：R595.4[医药卫生—内科学]