可见光诱导的烯烃和全氟烷基碘环化合成含氟羟吲哚  

Visible-Light-Induced Cyclization of Alkenes and Perfluoroalkyl Iodides to Synthesize Fluorinated Oxindoles

作　　者：何瑾 张红艳 刘婷 徐振华 唐石[1] He Jin;Zhang Hongyan;Liu Ting;Xu Zhenhua;Tang Shi(College of Chemistry and Chemical Engineering,Jishou University,Jishou 416000;College of Biomedical Engineering,Taiyuan University of Technology,Jinzhong 030600,China)

机构地区：[1]吉首大学化学化工学院,湖南吉首416000 [2]太原理工大学生物医学工程学院,山西晋中030600

出　　处：《广东化工》2023年第5期5-7,共3页Guangdong Chemical Industry

摘　　要：羟吲哚类化合物是一类具有生理活性和药理活性的分子,对其进行简单合成具有重要的意义。目前已知的合成羟吲哚类化合物的方法多数存在反应条件较为苛刻的问题。开发了一种实用的可见光诱导的烯烃环化反应,在铱催化剂的作用下,合成了各种含不同取代基的羟吲哚类化合物,且反应条件温和。机理研究表明,催化反应通过全氟烷基自由基引发的串联环化途径进行。Oxindoles are a class of molecules with physiological and pharmacological activities,and their simple synthesis is of great significance.The currently known methods for synthesizing oxindole compounds generally have the problem of harsh reaction conditions.A practical visible-light-induced alkene cyclization was developed.Various oxindoles with different substituents were synthesized under the action of iridium catalyst under mild reaction conditions.Mechanistic studies show that the catalytic reaction proceeds through a tandem cyclization pathway initiated by perfluoroalkyl radicals.

关 键 词：N-芳基类甲基丙烯酰胺 全氟烷基碘 羟吲哚 光催化 环加成 

分 类 号：O625.626[理学—有机化学]