大麻二酚环糊精包合物的制备及表征  

eparation and Characterization of Cannabidiol/Cyclodextrin Inclusion Complex

作　　者：郎圆 王金兰[1,2] 赵英楠 王丹 孙立秋[1,2] 李军 时志春 赵明[1,2] 张树军 Lang Yuan;Wang Jinlan;Zhao Yingnan;Wang Dan;Sun Liqiu;Li Jun;Shi Zhichun;Zhao Ming;Zhang Shujun(Institute of Chemistry and Chemical Engineering,Qiqihar University,Qiqihar 161000;Technology Innovation Center of Industrial Hemp for State Market Regulation,Qiqihar University,Qiqihar 161006,China)

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161000 [2]国家市场监管技术创新中心(工业大麻),黑龙江齐齐哈尔161006

出　　处：《广东化工》2023年第6期42-45,共4页Guangdong Chemical Industry

基　　金：齐齐哈尔市科技局重点攻关项目(ZDGG-202002)。

摘　　要：以2-羟丙基-β-环糊精(2-hydroxypropyl-β-cyclodextrin,HP-β-CD)为主体,大麻二酚(cannabidiol,CBD)为客体,无水乙醇作溶剂,采用磁力搅拌-旋转蒸发法制备CBD/HP-β-CD包合物,并通过单因素实验确定了最佳包合条件:包合温度为30℃、包合时间为12 h、搅拌速度为400 r/min。利用扫描电子显微镜,X射线衍射、傅立叶红外光谱、核磁共振等方法对包合物进行表征,并通过高效液相法测定了CBD在水中的溶解度:当按照摩尔比5∶1投料时,测得包合率为16.72%,溶解度为2.426μg/mL,提高了105倍。With 2-hydroxypropyl-β-Cyclodextrin(HP-β-CD)as the host,cannabidiol(CBD)as the guest.The inclusion complex was prepared by rotary evaporation method with anhydrous ethanol as solvent.The optimum inclusion conditions were determined by single factor experiments:the inclusion temperature is 30℃,the inclusion time is 12 h,and the stirring speed is 400 r/min.The inclusion complex was characterized by SEM,XRD,FT-IR and 1 H NMR,and the water solubility of CBD was determined by HPLC.According to the molar ratio of 5∶1,the inclusion rate was 16.72%and the water solubility was 2.426µg/mL,an increase of 105-fold.

关 键 词：大麻二酚 2-羟丙基-Β-环糊精 包合物 制备 表征 

分 类 号：TQ[化学工程]