细胞因子在猪胚胎附植期的作用及机制  

Roles and Mechanisms of Cytokines in Porcine Embryo Implantation Stage

作　　者：潘旭静 常俊磊 吴德[1] 徐盛玉[1] PAN Xujing;CHANG Junlei;WU De;XU Shengyu(Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,China)

机构地区：[1]四川农业大学动物营养研究所,成都611130

出　　处：《动物营养学报》2023年第3期1387-1395,共9页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金青年项目(32102554);四川省自然科学基金青年项目(2022NSFSC1628)。

摘　　要：猪胚胎的附植是通过广泛的细胞运动和重塑发生。胚胎的成功附植主要取决于胚胎延伸和滋养外胚层与子宫内膜上皮紧密连接的成功,这种紧密连接保证了孕体摄取其存活所必需的子宫腺上皮分泌物质。这些过程需要子宫和胚胎来源的细胞因子完成子宫内膜和滋养外胚层之间的细胞重塑,营造胚胎附植时的促炎微环境,维持附植阶段免疫系统的平衡,协调子宫和胚胎之间的相互作用等。本文主要综述了猪胚胎附植时期,由子宫和胚胎来源的细胞因子包括白细胞介素-1β(IL-1β)、干扰素(IFN)、成纤维细胞生长因子(FGF)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β(TGF-β)发挥的作用及其作用机理,以期为胚胎附植及发育调控相关研究提供参考。Implantation of porcine embryos occurs through extensive cell motility and remodeling.The successful implantation of the embryo depends primarily on the success of the embryo in extending and nourishing the tight connection between the trophectoderm and the endometrial epithelium,which ensures that the gestational body takes up the secretory substances of the uterine gland epithelium necessary for its survival.These processes require uterine and embryo-derived cytokines to complete cell remodeling between endometrium and trophoblast ectoderm,create pro-inflammatory microenvironment during embryo attachment,maintain the balance of immune system during implantation,and coordinate the interaction between uterus and embryo.This paper mainly reviewed the roles and mechanisms of uterine and embryonic-derived cytokines including interleukin-1β(IL-1β),interferon(IFN),fibroblast growth factor(FGF),tumor necrosis factor-α(TNF-α)and transforming growth factor-β(TGF-β)during the implantation period of porcine embryos,in order to provide reference for the research of embryo attachment and development regulation.

关 键 词：胚胎附植 子宫内膜 滋养外胚层 猪 细胞因子 

分 类 号：S828[农业科学—畜牧学]