Evaluation of immunoprotection against coronavirus disease 2019:Novel variants,vaccine inoculation,and complications  

作　　者：Congshan Jiang Kaichong Jiang Xiaowei Li Ning Zhang Wenhua Zhu Liesu Meng Yanmin Zhang Shemin Lu 

机构地区：[1]National Regional Children's Medical Center(Northwest),Key Laboratory of Precision Medicine to Pediatric Diseases of Shaanxi Province,Xi'an Key Laboratory of Children's Health and Diseases,Shaanxi Institute for Pediatric Diseases,Xi'an Children's Hospital,Affiliated Children's Hospital of Xi'an Jiaotong University,Xi'an,710003,China [2]National Joint Engineering Research Center of Biodiagnostics and Biotherapy,Second Affiliated Hospital,Xi'an Jiaotong University,Xi'an,710004,China [3]Key Laboratory of Environment and Genes Related to Diseases,Xi'an Jiaotong University,Xi'an,710061,China [4]Institute of Molecular and Translational Medicine(IMTM),and Department of Biochemistry and Molecular Biology,Xi'an Jiaotong University Health Science Center,Xi'an,710061,China

出　　处：《Journal of Pharmaceutical Analysis》2023年第1期1-10,共10页药物分析学报（英文版）

基　　金：support from the National Natural Science Foundation of China(Grant Nos.:81970029,81974014,82211530115,and 81470452),China Postdoctoral Science Foundation(Project No.:2021M702591),the Natural Science Foundation of Shaanxi Province(Project No.:2021JQ-024),Fundamental Research Funds for the Central Universities(Project No.:xjh012020026),Xi'an Health Commission(COVID-19 special project),Xi'an Talent Program(Project No.:XAYC200023),and research funds of Xi'an Children's Hospital(Project No.:2020A03).

摘　　要：The strikingly rapidly mutating nature of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)genome has been a constant challenge during the coronavirus disease 2019(COVID-19)pandemic.In this study,various techniques,including reverse transcription-quantitative polymerase chain reaction,antigen-detection rapid diagnostic tests,and high-throughput sequencing were analyzed under different scenarios and spectra for the etiological diagnosis of COVID-19 at the population scale.This study aimed to summarize the latest research progress and provide up-to-date understanding of the methodology used for the evaluation of the immunoprotection conditions against future variants of SARS-CoV-2.Our novel work reviewed the current methods for the evaluation of the immunoprotection status of a specific population(endogenous antibodies)before and after vaccine inoculation(administered with biopharmaceutical antibody products).The present knowledge of the immunoprotection status regarding the COVID-19 complications was also discussed.Knowledge on the immunoprotection status of specific populations can help guide the design of pharmaceutical antibody products,inform practice guidelines,and develop national regulations with respect to the timing of and need for extra rounds of vaccine boosters.

关 键 词：COVID-19Etiological diagnosisImmunoprotectionSARS-CoV-2 variantsVaccineComplications 

分 类 号：R563.1[医药卫生—呼吸系统]