血清25羟维生素D与心力衰竭患者射血分数的相关性  

Relationship between serum 25 hydroxyvitamin D and ejection fraction in patients with heart failure

作　　者：惠睿 艾力曼·马合木提[1] 徐玲[1] 郭玉君[1] 努尔比牙·吾买尔 丁慧敏 HUI Rui;Ailiman·Mahemuti;XU Ling;GUO Yujun;Nuerbiya·Wumaier;DING Huimin(Department of Heart Failure,The First Affiliated Hospital of Xinjiang Medical University,Urumqi,830000,China)

机构地区：[1]新疆医科大学第一附属医院心力衰竭科,乌鲁木齐830000

出　　处：《临床心血管病杂志》2023年第2期154-159,共6页Journal of Clinical Cardiology

基　　金：新疆维吾尔自治区自然科学基金重点项目(No:2021D01D17)。

摘　　要：目的:分析血清25羟维生素D[25(OH)D]与心力衰竭(心衰)患者射血分数的相关性。方法:纳入427例心衰患者,将其分为射血分数降低的心衰(HFrEF)组145例、射血分数中间值的心衰(HFmrEF)组145例和射血分数保留的心衰(HFpEF)组137例。另纳入同期的健康体检者153例为对照组。收集一般临床资料、常规生化指标、血清25(OH)D、N末端B型脑钠肽前体(NT-proBNP)及超声心动图的相关指标,分析不同心衰组患者临床特征及其与血清25(OH)D水平的相关性。结果:对照组血清25(OH)D水平和左室射血分数(LVEF)显著高于各心衰组(均P<0.05),NT-proBNP表达水平显著低于各心衰组(均P<0.05)。HFrEF组25(OH)D水平显著低于HFmrEF组与HFpEF组,NT-proBNP水平显著高于HFmrEF组与HFpEF组(均P<0.05);HFmrEF组与HFpEF组间25(OH)D和NT-proBNP水平均差异无统计学意义。Spearman相关性分析显示,血清25(OH)D与RVOT、PAP、NT-proBNP均呈弱负相关性(r=-0.131、-0.105、-0.187,均P<0.05),与FS、LVEF、SV均呈弱正相关性(r=0.136、0.128、0.115,均P<0.05)。多元线性回分析结果显示,HFpEF组血清25(OH)D与LVEF存在线性关系(P<0.05)。结论:心衰患者普遍缺乏血清25(OH)D,且HFrEF患者血清25(OH)D水平最低。血清25(OH)D水平与LVEF呈弱正相关性。Objective:To analyze the relationship between serum 25 hydroxyvitamin D(25[OH]D)and ejection fraction in patients with heart failure.Methods:A total of 427 heart failure patients were divided into the heart failure with reduced ejection fraction(HFrEF)group(LVEF<40%,n=145),heart failure with mid-range ejection fraction(HFmrEF)group(40%≤LVEF<49%,n=145),and heart failure with preserved ejection fraction(HFpEF)group(LVEF≥50%,n=137).Other 153 healthy physical examiners were included into the control group.General clinical data,routine biochemical indexes,serum 25(OH)D,NT-proBNP,and echocardiographic indexes were collected.Clinical characteristics and their correlation with serum 25(OH)D levels in heart failure patients were analyzed.Results:The serum 25(OH)D level and LVEF in the control group were significantly higher than those in heart failure groups(all P<0.05),and the NT-proBNP level was significantly lower than those in heart failure groups(all P<0.05).The 25(OH)D level in the HFrEF group was significantly lower than those in the HFmrEF group and HFpEF group,and the NT-proBNP level was significantly higher than those in the HFmrEF group and HFpEF group(all P<0.05);There was no significant difference in 25(OH)D and NT-proBNP levels between the HFmrEF group and HFpEF group.Spearman correlation analysis showed that serum 25(OH)D was weakly negatively correlated with RVOT,PAP,and NT-proBNP(r=-0.131,-0.105,-0.187,all P<0.05),and weakly positively correlated with FS,LVEF and SV(r=0.136,0.128,0.115,all P<0.05).Multiple linear regression analysis showed that there was a linear relationship between serum 25(OH)D and LVEF in the HFpEF group(P<0.05).Conclusion:Patients with heart failure are generally deficient in serum 25(OH)D,and patients with HFrEF have the lowest serum 25(OH)D levels.There is a weak positive correlation between serum 25(OH)D level and LVEF.

关 键 词：心力衰竭 25羟维生素D 射血分数 

分 类 号：R541.6[医药卫生—心血管疾病]