老年重症社区获得性肺炎患者血清8-iso-PGF2α、S100A12水平变化及临床意义  

Changes and clinical significance of serum 8-iso-PFG2αand S100A12 levels in elderly patients with severe community-acquired pneumonia

作　　者：朱娅丽[1] 杜维桓[1] 张巍 李德善 陈济超[2] 张依[1] ZHU Ya-li;DU Wei-huan;ZHANG Wei;LI De-shan;CHEN Ji-chao;ZHANG Yi(Department of Geriatrics,Aerospace Center Hospital,Beijing 100049,China;Department of Respiratory,Aerospace Center Hospital,Beijing 100049,China)

机构地区：[1]航天中心医院老年医学科,北京100049 [2]航天中心医院呼吸科,北京100049

出　　处：《临床肺科杂志》2023年第4期563-567,共5页Journal of Clinical Pulmonary Medicine

基　　金：吴阶平医学基金会临床科研专项资助基金(No.320.6750.19089-2)。

摘　　要：目的探讨老年重症社区获得性肺炎(SCAP)患者血清8异前列腺素F2α(8-iso-PGF2α)、钙卫结合蛋白S100A12(S100A12)水平变化及临床意义。方法选取136例SCAP作为研究组,同时选取68例同期健康体检人群作为对照组。根据患者28天预后情况分为生存组(94例)和死亡组(42例)。比较两组基本资料,应用多因素Logistic回归分析老年SCAP患者预后的影响因素;同时应用受试者工作(ROC)曲线和生存曲线分析血清8-iso-PGF2α、S100A12对老年SCAP患者预后的临床价值。结果研究组血清8-iso-PGF2α、S100A12水平高于对照组(P<0.05),死亡组血清8-iso-PGF2α、S100A12水平高于生存组(P<0.05)。多因素Logistic回归分析显示,PSI评分、CURB-65评分、8-iso-PGF2α和S100A12是老年SCAP患者预后的影响因素。ROC曲线显示,血清8-iso-PGF2α、S100A12联合预测老年SCAP患者预后临床价值优于两者单独应用。血清8-iso-PGF2α≥34.78 pg/mL、S100A12≥26.98 ng/mL患者与8-iso-PGF2α<34.78 pg/mL、S100A12<26.98 ng/mL患者生存曲线差异有显著性(P均<0.001)。结论老年SCAP患者血清8-iso-PGF2α、S100A12水平升高,与患者预后密切相关,可作为预测老年SCAP患者预后的标志物,但两者联合应用价值优于单独应用。Objective To investigate the changes and clinical significance of the serum 8-iso-prostaglandin-F2alpha(8-iso-PGF2α)and calprotectin S100A12(S100A12)in elderly patients with severe community-acquired pneumonia(SCAP).Methods A total of 136 elderly patients with SCAP were selected as the study group,and 68 healthy people during the same period were selected as the control group.The patients were divided into the survival group(94 cases)and the death group(42 cases)according to their 28-day prognosis.The basic data of the two groups were compared.Multivariate logistic regression was used to analyze the prognostic factors of elderly patients with SCAP,and serum 8-iso-PGF2αand S100A12 were used to estimate the prognosis of elderly patients with SCAP by receiver operating curve(ROC)and survival curve.Results Serum 8-iso-PGF2αand S100A12 levels in the study group were higher than those in the control group(P<0.05),and 8-iso-PGF2αand S100A12 levels in the death group were higher than those in the survival group(P<0.05).Multivariate logistic regression analysis showed that PSI score,CURB-65 score,8-iso-PGF2αand S100A12 were the prognostic factors in elderly patients with SCAP.ROC curve showed that the value of combined use of 8-iso-PGF2αand S100A12 was better than that of single use.Survival curve analysis showed that serum 8-iso-PGF2α≥34.78 pg/ml and S100A12≥26.98 ng/ml,the cumulative survival rate of elderly patients with SCAP were significantly lower than those of 8-iso-PGF2α<34.78 pg/ml,S100A12<26.98 ng/ml(all P<0.001).Conclusion Serum 8-iso-PGF2αand S100A12 level elevates in elderly patients with SCAP,which are closely related to the prognosis of patients.It could be used as a prognostic marker in elderly patients with SCAP,but the value of combined use of 8-iso-PGF2αand S100A12 is better than that of single use.

关 键 词：社区获得性肺炎 8异前列腺素F2α 钙卫结合蛋白S100A12 预后 

分 类 号：R563.1[医药卫生—呼吸系统]