25-羟维生素D和乳酸脱氢酶检测B族溶血性链球菌感染新生儿的临床意义  

Clinical significance of 25⁃hydroxyvitamin D and lactate dehydrogenase in detecting neonates infected with group B hemolytic Streptococcus

作　　者：乔木[1] 韩雁雁 姚文秀[1] QIAO Mu;HAN Yanyan;YAO Wenxiu(Department of Neonatology,the First Hospital of Qinhuangdao in Hebei Province,Qinhuangdao,Hebei,066000)

机构地区：[1]河北省秦皇岛市第一医院新生儿科,河北秦皇岛066000

出　　处：《实用临床医药杂志》2023年第4期44-47,65,共5页Journal of Clinical Medicine in Practice

基　　金：秦皇岛市科学技术研究与发展计划(202004A065)。

摘　　要：目的探讨25-羟维生素D[25-(OH)D]、乳酸脱氢酶(LDH)在新生儿B族溶血性链球菌(GBS)感染败血症患儿血清中的水平变化及其临床意义。方法选取204例GBS感染患儿为研究对象,根据是否发生败血症分为GBS感染组103例和败血症组101例,另选取同期健康新生儿105例作为对照组。检测血清25-(OH)D、LDH水平并分析二者相关性;采用受试者工作特征(ROC)曲线评估25-(OH)D、LDH对新生儿GBS感染败血症的预测价值;分析新生儿GBS感染败血症的影响因素。结果GBS感染组患儿血清25-(OH)D水平低于对照组,LDH水平高于对照组,差异有统计学意义(P<0.05);败血症组患儿血清25-(OH)D水平低于GBS感染组,LDH水平高于GBS感染组,差异有统计学意义(P<0.05)。新生儿GBS感染败血症患儿血清25-(OH)D、LDH水平呈负相关(P<0.05);25-(OH)D、LDH联合预估新生儿GBS感染败血症的ROC曲线下面积(AUC)大于25-(OH)D、LDH单独预估(P<0.05)。血清25-(OH)D、LDH是影响新生儿GBS感染败血症发生的危险因素(P<0.05)。结论新生儿GBS感染败血症患儿血清25-(OH)D水平异常降低,LDH水平异常升高,检测二者水平对早期预估、防治新生儿GBS感染败血症有重要意义。Objective To investigate the changes in serum levels of 25⁃hydroxyvitamin D[25⁃(OH)D]and lactate dehydrogenase(LDH)in neonates with sepsis induced by group B hemo⁃lytic streptococcus(GBS)and their clinical significance.Methods A total of 204 children with GBS infection were elected as research objects.According to the occurrence condition of sepsis,they were divided into GBS infection group(n=103)and sepsis group(n=101),and 105 cases of healthy newborns were selected as control group.The serum 25⁃(OH)D and LDH levels were detected and their correlation was analyzed;the predictive value of 25⁃(OH)D and LDH for neonatal GBS⁃infected sepsis was evaluated by receiver operating characteristic(ROC)curve;the influencing factors of neo⁃natal GBS infection sepsis were analyzed.Results The serum 25⁃(OH)D level of children in the GBS infection group was significantly lower than that in the control group,and the LDH level was sig⁃nificantly higher than that in the control group(P<0.05);the serum 25⁃(OH)D level of children in the sepsis group was significantly lower than that in the GBS infection group,and the LDH level was significantly higher than that in the GBS infection group(P<0.05).The levels of serum 25⁃(OH)D and LDH were negatively correlated in those of neonatal GBS infected with sepsis(P<0.05);the ar⁃ea under ROC curve(AUC)of 25⁃(OH)D and LDH combined predicted neonatal GBS infection with sepsis was greater than that of 25⁃(OH)D and LDH separately assessed(P<0.05).Serum 25⁃(OH)D and LDH were risk factors for neonatal GBS infection with sepsis(P<0.05).Conclusion The serum 25⁃(OH)D level is abnormally decreased and LDH level is abnormally increased in neonates with GBS infected sepsis.The detection of both levels is of great significance for early prediction and prevention of neonatal GBS infected sepsis.

关 键 词：新生儿 B族溶血性链球菌 败血症 25-羟维生素D 乳酸脱氢酶 

分 类 号：R722.13[医药卫生—儿科] R446.11[医药卫生—临床医学]