乙酰氨基酚联合水合氯醛灌肠治疗高热惊厥患儿的临床效果及对体液免疫功能、脑神经因子的影响  

Clinical effect of Acetaminophen combined with Chloral Hydrate Enema in the treatment of children with febrile convulsion and its influence on humoral immune function and brain nerve factor

作　　者：孔令娟 KONG Lingjuan(Qufu People’s Hospital,Shandong Province,Qufu 273100,China)

机构地区：[1]山东省曲阜市人民医院,山东曲阜273100

出　　处：《妇儿健康导刊》2023年第6期114-116,共3页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨乙酰氨基酚联合水合氯醛灌肠治疗高热惊厥患儿的临床效果及对体液免疫功能、脑神经因子的影响。方法选取2020年1月至2021年1月曲阜市人民医院收治的80例高热惊厥患儿作为研究对象,按照随机数字表法分为对照组和观察组,每组各40例。对照组采用乙酰氨基酚治疗,观察组在对照组基础上联合水合氯醛灌肠治疗。比较两组治疗效果、体液免疫功能及脑神经因子。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组免疫球蛋白A及免疫球蛋白G水平均高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组神经元特异性烯醇化酶(NSE)水平低于治疗前,且观察组低于对照组(P<0.05)。结论高热惊厥患儿采用乙酰氨基酚联合水合氯醛灌肠治疗,疗效显著,可改善患儿免疫功能及NSE水平,值得临床推广应用。Objective To investigate the clinical effect of Acetaminophen combined with Chloral Hydrate Enema in the treatment of children with febrile convulsion and its influence on humoral immune function and brain nerve factor.Methods A total of 80 children with febrile convulsion admitted to Qufu People’s Hospital from January 2020 to January 2021 were selected as the research objects and divided into the control group and the observation group according to the random number table method,with 40 cases in each group.The control group was treated with Acetaminophen,and the observation group was treated with Chloral Hydrate Enema based on the control group.The therapeutic effect,humoral immune function and brain nerve factor of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the immunoglobulin A and immunoglobulin G levels in both groups were higher than those before treatment,and those in the observation group were higher than those in the control group(P<0.05).After treatment,the level of neuron-specific enolase(NSE)in both groups was lower than that before treatment,and that in the observation group was lower than that in the control group(P<0.05).Conclusion Acetaminophen combined with Chloral Hydrate Enema treatment in children with febrile convulsion has a significant effect,which can improve the immune function and NSE level of children,and is worthy of clinical application.

关 键 词：乙酰氨基酚 水合氯醛灌肠 高热惊厥 体液免疫功能 神经元特异性烯醇化酶水平 

分 类 号：R720.597[医药卫生—急诊医学]