阿司匹林联合替格瑞洛在急性ST段抬高型心肌梗死院前急救治疗中的临床应用价值分析  

Clinical value analysis of aspirin combined with ticagrelor in pre-hospital emergency treatment of acute ST-segment elevation myocardial infarction

作　　者：贺兰[1] HE Lan(Clinical Skills Training Center,Liaocheng People's Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市人民医院临床技能培训中心,252000

出　　处：《中国实用医药》2023年第5期7-10,共4页China Practical Medicine

摘　　要：目的对急性ST段抬高型心肌梗死患者展开医治,观察阿司匹林联合替格瑞洛在院前急救中的效果。方法40例急性ST段抬高型心肌梗死患者,经由系统抽样分为实验组及对照组,每组20例。对照组院前急救中采用氯吡格雷联合阿司匹林治疗,实验组院前急救中采用阿司匹林联合替格瑞洛治疗。比较两组治疗效果、心功能指标[左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、左心室射血分数(LVEF)]水平、生活质量评分以及治疗前后血清尿素氮(BUN)、肌酐(Cr)、氨基末端脑钠肽前体(NT-proBNP)水平。结果实验组治疗总有效率为90.00%,高于对照组的60.00%,差异有统计学意义(P<0.05)。实验组LVEDV(238.32±23.15)ml、LVESV(161.53±17.16)ml小于对照组的(254.48±24.87)、(176.84±17.91)ml,LVEF(35.81±3.62)%高于对照组的(28.54±3.96)%,差异有统计学意义(P<0.05)。实验组心理功能评分为(80.16±4.28)分、物质生活状态评分为(81.28±4.61)分、社会功能评分为(80.13±3.24)分,均高于对照组的(71.37±4.64)、(72.13±4.62)、(70.92±3.13)分,差异有统计学意义(P<0.05)。治疗前,两组血清BUN、Cr、NT-proBNP水平比较,差异无统计学意义(P>0.05);治疗后,实验组患者的血清BUN为(5.68±1.36)mmol/L、Cr为(100.26±10.36)μmol/L、NT-proBNP为(1216.49±124.56)ng/L,均低于对照组的(6.73±1.44)mmol/L、(108.86±15.69)μmol/L、(1406.46±189.56)ng/L,差异有统计学意义(P<0.05)。结论阿司匹林联合替格瑞洛应用于急性ST段抬高型心肌梗死患者院前急救中,效果更好,患者的症状得到了明显的缓解,其心功能情况也得到了较好的改善,患者自身的生活水平也随之上升。Objective To observe the effect of aspirin combined with ticagrelor in pre-hospital emergency treatment of patients with acute ST-segment elevation myocardial infarction.Methods A total of 40 patients with acute ST-segment elevation myocardial infarction were divided into experimental group and control group by systematic sampling,with 20 patients in each group.The control group was treated with clopidogrel and aspirin in pre-hospital emergency,and the experimental group was treated with aspirin and ticagrelor in pre-hospital emergency.Both groups were compared in terms of therapeutic effect,cardiac function indexes[left ventricular end diastolic volume(LVEDV),left ventricular end systolic volume(LVESV),left ventricular ejection fraction(LVEF)],quality of life score,and blood urea nitrogen(BUN),creatinine(Cr),N-terminal pro-brain natriuretic peptide(NT-proBNP)levels before and after treatment.Results The total effective rate of the experimental group was 90.00%,which was higher than 60.00%of the control group,and the difference was statistically significant(P<0.05).The experimental group had LVEDV of(238.32±23.15)ml and LVESV of(161.53±17.16)ml,which were less than(254.48±24.87)and(176.84±17.91)ml in the control group;the LVEF(35.81±3.62)%in the experimental group was higher than(28.54±3.96)%in the control group;the differences were statistically significant(P<0.05).The psychological function score of the experimental group was(80.16±4.28)points,the material life status score was(81.28±4.61)points,the social function score was(80.13±3.24)points,which were higher than(71.37±4.64),(72.13±4.62),(70.92±3.13)points of the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in serum BUN,Cr and NT-proBNP levels between the two groups(P>0.05).After treatment,the serum BUN of the experimental group was(5.68±1.36)mmol/L,Cr was(100.26±10.36)μmol/L,NT-proBNP was(1216.49±124.56)ng/L,which were lower than(6.73±1.44)mmol/L,(

关 键 词：阿司匹林 替格瑞洛 急性ST段抬高型心肌梗死 院前急救治疗 价值 

分 类 号：R542.22[医药卫生—心血管疾病]