经鼻高流量湿化氧疗在呼吸衰竭低氧血症患者中的应用效果分析  

Effect analysis of transnasal high-flow humidification oxygen therapy in patients with hypoxemia of respiratory failure

作　　者：施红伟[1] 刘春峰[1] 姚炳荣[1] 陈瑢 马腾飞 SHI Hong-wei;LIU Chun-feng;YAO Bing-rong(Department of Critical Medicine,Rudong County People's Hospital,Nantong 226400,China)

机构地区：[1]如东县人民医院重症医学科,226400

出　　处：《中国实用医药》2023年第5期21-24,共4页China Practical Medicine

摘　　要：目的分析呼吸衰竭低氧血症患者实施经鼻高流量湿化氧疗治疗的效果。方法100例呼吸衰竭低氧血症患者作为研究对象,以随机法分为对照组和观察组,每组50例。两组患者均实施抗感染、营养支持、气管插管机械通气治疗,病情稳定后拔除气管插管,对照组患者采用面罩吸氧治疗,观察组患者采用经鼻高流量湿化氧疗治疗。对比两组患者不同时间点血气指标(动脉血氧分压、动脉血二氧化碳分压)水平,重症加强护理病房(ICU)停留时间、住院时间,不同时间点心率和平均动脉压水平,并发症发生情况与气管再插管率。结果两组患者拔管即刻、拔管后2 h的动脉血氧分压、动脉血二氧化碳分压水平比较,差异均无统计学意义(P>0.05)。观察组患者ICU停留时间、住院时间分别为(4.93±1.58)d和(8.98±1.83)d,均短于对照组的(7.57±1.72)d和(12.36±2.17)d,差异具有统计学意义(P<0.05)。拔管即刻,两组患者的心率和平均动脉压水平对比差异无统计学意义(P>0.05);拔管后6、12 h,观察组患者的心率分别为(79.64±5.25)、(75.63±5.44)次/min,均低于对照组的(88.77±6.10)、(91.16±5.46)次/min,差异具有统计学意义(P<0.05);两组患者拔管后6、12 h平均动脉压水平对比差异无统计学意义(P>0.05)。观察组患者的并发症发生率0低于对照组的10.0%,差异具有统计学意义(P<0.05);观察组患者治疗期间的气管再插管率为4.0%(2/50),与对照组的6.0%(3/50)对比,差异无统计学意义(P>0.05)。结论经鼻高流量湿化氧疗治疗呼吸衰竭低氧血症患者具有较好的效果,能够缩短患者的治疗时间,整体疗效更好,且能提高患者的依从性,值得推广应用。Objective To analyze the effect of transnasal high-flow humidification oxygen therapy in patients with hypoxemia of respiratory failure.Methods A total of 100 patients with hypoxemia of respiratory failure were studied and randomly divided into a control group and an observation group,with 50 cases in each group.Patients in both groups were treated with anti-infection,nutritional support and mechanical ventilation with tracheal intubation,and tracheal intubation was removed after the condition became stable.Patients in the control group were treated with mask oxygen therapy,and patients in the observation group were treated with transnasal high-flow humidification oxygen therapy.Both groups were compared in terms of levels of blood gas indexes(arterial partial pressure of oxygen,arterial partial pressure of carbon dioxide)at different time points,intensive care unit(ICU)stay time,hospitalization time,heart rate and mean arterial pressure level at different time points,occurrence of complications and reintubation rate.Results There was no statistically significant difference in the levels of arterial partial pressure of oxygen and arterial partial pressure of carbon dioxide between the two groups immediately after extubation and 2 h after extubation(P>0.05).The ICU stay and hospitalization time in the observation group were(4.93±1.58)and(8.98±1.83)d,which were shorter than(7.57±1.72)and(12.36±2.17)d in the control group,and the differences were statistically significant(P<0.05).Immediately after extubation,there was no statistically significant difference in heart rate and mean arterial pressure levels between the two groups(P>0.05).At 6 and 12 h after extubation,the heart rates in the observation group were(79.64±5.25)and(75.63±5.44)beats/min,which were lower than(88.77±6.10)and(91.16±5.46)beats/min in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the mean arterial pressure level between the two groups at 6 and 12 h after

关 键 词：经鼻高流量湿化氧疗 呼吸衰竭 低氧血症 血气指标 并发症 

分 类 号：R563.8[医药卫生—呼吸系统] R459.6[医药卫生—内科学]