光学成像技术在中医针刺研究中的应用进展  

Application of Optical Imaging for Studying Chinese Acupuncture:a Review

作　　者：许越 聂立铭 Xu Yue;Nie Liming(Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,Fujian,China;Optical Molecular Imaging Laboratory,Research Center of Medical Sciences,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,Guangdong,China)

机构地区：[1]厦门大学公共卫生学院分子影像暨转化医学研究中心,福建厦门361102 [2]广东省医学科学院/广东省人民医院,医学研究部,光学分子影像实验室,广东广州510080

出　　处：《中国激光》2023年第3期65-77,共13页Chinese Journal of Lasers

摘　　要：以针刺和拔罐疗法为代表的中医理疗被用于治疗肌肉骨骼疾病、缓解疼痛症状已有数千年的历史。中医理疗以疗效显著、安全性高的优势在全球流行。然而,传统的中医理论对于针刺疗法治疗机制的解释缺乏有效的科学证据,而且大多数针刺疗法的疗效缺乏有效的定量评估,无法保证其治疗效果及安全性。凭借高分辨率、高对比度、高安全性等特点,光学成像技术在针刺疗法的机制研究与疗效评估方面展现出了巨大潜力。目前用于研究针刺疗法的光学成像技术主要有激光多普勒血流灌注成像、激光散斑成像、近红外光谱成像和光声成像等,它们分别在针刺的血流动力学效应、大脑响应、治疗机制与疗效评估等方面取得了一定进展,但目前鲜见系统总结上述光学成像技术应用于针刺疗法研究的报道。鉴于此,本文系统介绍了这几类光学成像技术的特点以及它们在针刺疗法研究中的应用情况,并展望了其临床研究前景。Significance Traditional Chinese physiotherapy,primarily represented by acupuncture and cupping,has been employed for thousands of years to treat musculoskeletal diseases and relieve pain symptoms.Acupuncture is popular worldwide owing to its remarkable curative efficacy and safety.However,the theory of traditional Chinese medicine fails to provide substantial scientific evidence to clarify the mechanisms underlying acupuncture treatment.Moreover,most acupuncture therapies lack effective scientific assessment during treatment,failing to ensure their efficacy and safety.Optical imaging can be used to propagate light in cells and tissues,combine various molecular probes to image organs,and safely obtain robust biological information.Optical imaging is optimal for observing the vascular structures of biological tissues,as well as for monitoring local hemodynamic changes.Optical imaging techniques employed to examine acupuncture primarily include laser Doppler blood perfusion imaging(LDPI),laser speckle imaging(LSI),nearinfrared spectroscopy(NIRS),and photoacoustic imaging(PAI).Considerable progress has been made with regard to measuring hemodynamic effects,brain response,therapeutic mechanisms,and the curative effect of acupuncture.However,a systematic summary of these findings is lacking.This review helps readers in the field of traditional Chinese medicine to establish a comprehensive understanding of diverse optical imaging techniques and outline their recent advancements in acupuncture research.Progress This review briefly introduces the characteristics of different types of optical imaging and their progress in assessing acupuncture.In addition,their limitations and development directions are summarized.LDPI and LSI use noncontact data acquisition,with advantages such as noninvasiveness and rapid scanning and eliminating certain hidden dangers generated by contact imaging systems.Measuring the improvement in blood circulation at specific sites using LDPI and LSI can assess the efficacy of acupuncture and reveal

关 键 词：医用光学 针刺疗法 光学成像技术 激光多普勒 激光散斑成像 近红外光谱 光声成像 

分 类 号：TH773[机械工程—仪器科学与技术] R246.[机械工程—精密仪器及机械]