血管内光声-超声-光学相干层析-光声弹性多模态成像方法及系统  

Intravascular Photoacoustic,Ultrasonic,Optical Coherence Tomography,and Photoacoustic Elastic Multimodal Imaging Method and System

作　　者：万余洋 雷鹏 熊科迪 杨思华 Wan Yuyang;Lei Peng;Xiong Kedi;Yang Sihua(MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science,College of Biophotonics,South China Normal University,Guangzhou 510631,Guangdong,China;Guangdong Provincial Key Laboratory of Laser Life Science,College of Biophotonics,South China Normal University,Guangzhou 510631,Guangdong,China;Institute of Biological and Medical Engineering,Guangdong Academy of Sciences,Guangzhou 510316,Guangdong,China)

机构地区：[1]华南师范大学生物光子学研究院,激光生命科学教育部重点实验室暨激光生命科学研究所,广东广州510631 [2]华南师范大学生物光子学研究院,广东省激光生命科学重点实验室,广东广州510631 [3]广东省科学院生物与医学工程研究所,广东广州510316

出　　处：《中国激光》2023年第3期86-95,共10页Chinese Journal of Lasers

基　　金：国家自然科学基金(61822505,61627827);广东省自然科学基金(2022A1515010548,2022A1515011247);广东省科学院建设国内一流研究机构行动专项资金项目(2021GDASYL20210103031);广州市科技计划项目(2019050001)。

摘　　要：识别动脉粥样硬化斑块的易损性是防治急性冠状动脉疾病的重要途径。纤维帽厚度、脂质核心大小、管腔狭窄程度和管腔的力学特性是评估斑块易损性的关键参数。然而,单一模态的血管内成像技术难以通过一次成像获取用于评估斑块易损性的全面信息。本团队通过复用光路和声路,将血管内超声成像(IVUS)和血管内光学相干层析成像(IVOCT)与血管内光声成像(IVPA)、光声弹性成像(IVPAE)有机结合到一起,开发了一种血管内光声-超声-光学相干层析-光声弹性四模态一体化成像探头及成像系统。该一体化成像探头的成像直径仅为0.97 mm,光学相干层析、光声、超声模态的横向分辨率分别为20.5、61.3、122.2μm,纵向分辨率分别为15.8、57.4、72.5μm。离体模拟样品和兔腹主动脉的在体成像实验验证了血管内四模态成像能够提供血管壁的宏观和微观结构信息,同时能够特异性识别脂质成分和反映脂质斑块的弹性力学信息。该一体化探头可一次性获取血管内斑块的多物理影像特性,有望为动脉粥样硬化斑块的深入理解和诊治提供新型的介入成像方法和工具。Objective Rupture of vulnerable plaques with thrombosis is one of the major causes of most acute coronary syndromes.Plaque vulnerability is highly correlated with plaque structure,composition,and mechanical properties,which are typically characterized by thin fibrous caps,lipidrich necrotic cores,and severe stenosis;in addition,plaque vulnerability is also influenced by the mechanomechanical properties of the vessel wall and plaque.Intravascular photoacoustic(IVPA)imaging is an emerging intravascular imaging modality that can provide submillimeter resolution at penetration depths up to several centimeters and is capable of localizing and imaging lipids with high sensitivity and specificity.Simultaneously,plaque elastography can be performed through the IVPA signals without additional excitation;subsequently,the elastic mechanical properties of plaque can be evaluated.Although intravascular ultrasonography(IVUS)and intravascular optical coherence tomography(IVOCT)have been widely used in the clinical evaluation of plaque diagnosis,the current single intravascular imaging technology cannot assess the vulnerability of atherosclerotic plaques.For a comprehensive diagnosis,the clinicians need to obtain multiple features to fully identify and evaluate plaques.In this study,we proposed and developed an intravascular multimodal system that integrates four imaging modalities,namely,PA,US,OCT,and PAE.The information on plaque based on these four modalities can be obtained from a single probe via 360°rotation and synchronous retraction in one time,which is expected to provide a new interventional imaging method and tools for the understanding,diagnosis,and treatment of atherosclerotic plaques.Methods The intravascular PAUSOCTPAE imaging system,which integrates the four subsystems of photoacoustic imaging,ultrasonic imaging,OCT,and photoacoustic elasticity,can be used to analyze the macroscopic and microscopic structural information of the blood vessel wall and to specifically identify the lipid components and to perform th

关 键 词：医用光学 光声成像 超声成像 光学相干层析成像 光声弹性成像 血管内多模态成像 

分 类 号：Q631[生物学—生物物理学]