人工心脏生物瓣膜的三维缺陷检测  

Three⁃Dimensional Defects Inspection of Bioprosthetic Valves

作　　者：姚霖 俞晨阳 刘开元 邓晓枫 丁志华[1] 李鹏[1,2] Yao Lin;Yu Chenyang;Liu Kaiyuan;Deng Xiaofeng;Ding Zhihua;Li Peng(College of Optical Science and Engineering,Zhejiang University,Hangzhou 310027,Zhejiang,China;Intelligent Optics&Photonics Research Center Jiaxing Research Institute,Zhejiang University,Jiaxing 324000,Zhejiang,China)

机构地区：[1]浙江大学光电科学与工程学院,浙江杭州310027 [2]浙江大学嘉兴研究院智能光电创新中心,浙江嘉兴324000

出　　处：《中国激光》2023年第3期96-101,共6页Chinese Journal of Lasers

基　　金：国家自然科学基金(62075189);浙江省自然科学基金(LR19F050002);之江实验室资助项目(2018EB0ZX01);浙江大学脑科学与脑机接口教育部前沿科学中心资助项目。

摘　　要：提出了一种基于光学相干层析成像(OCT)技术实现人工心脏生物瓣膜三维缺陷检测的方法,发展了一种生物瓣膜表面边界拟合算法。根据拟合结果进行坐标变换,使瓣膜表面边界趋于水平但保留表面纤维束高度和异常起伏的高频变化。利用所提方法对人工心脏生物瓣膜三尖瓣支架和其中的瓣膜小叶进行成像实验,实现了高分辨率、大视场、实时三维结构成像,成像结果可以显示生物瓣膜纤维层、光滑层、层间缺陷以及切割缺陷。该技术有望被广泛应用于人工心脏生物瓣膜制造检测领域。Objective Heart valve disease is a growing public health concern worldwide.A prosthetic heart valve is a heart implant intervention medical device for the treatment of heart valve disease,which mainly includes bioprosthetic and mechanical valves.Diseased native valves are often replaced with bioprosthetic valves made from porcine or bovine pericardium,which has a lower risk of thrombosis and hemodynamic advantages than mechanical valves.Nonetheless,bioprosthetic valves do not have longterm durability,mainly because of their early structural failure.Therefore,an in vitro fatigue test is required for manufactured bioprosthetic valves;further,it is very important to evaluate the quality of the valve after the fatigue test,thereby obtaining a basis for the optimization of valve performance.Methods The OCT light source was a MEMStunable vertical cavity surfaceemitting laser(VCSEL,Thorlabs,SL131090).The laser could sweep at a rate of 100 kHz over a broad spectral bandwidth of~100 nm with a center wavelength of 1300 nm,providing an experimental axial resolution of~16μm and an imaging depth of~11 mm in air.The output light from the laser source was first fibercoupled into an interferometer,where the light was split by an 80:20 fiber coupler into a sample arm and reference arm.In the OCT sample arm,a scanning lens(Thorlabs,LSM05)with an effective focal length of 54 mm was used to collimate the detection light on the sample,providing an experimental lateral resolution of~32μm,and an XY galvanometer was adopted for threedimensional(3D)volume scanning.The light backscattered from the sample was recombined with the light reflected from the reference mirror,and the interference signal was detected using a balanced detector(Thorlabs,PDB470C).A stepwise raster scanning protocol(ZXY)was used for volumetric imaging,with 1000 Alines per Bframe(fastscan,Xdirection)and 1000 Bframes at 1000 tomographic positions per volume(slowscan,Ydirection).OCT imaging covered a field of view(FOV)of 12 mm(X)×12 mm(Y)of the swine heart valve leaf

关 键 词：生物光学 生物医学成像 光学相干层析成像 人工心脏生物瓣膜 缺陷检测 

分 类 号：TN247[电子电信—物理电子学]