小儿牛黄清心散联合左乙拉西坦治疗小儿热性惊厥的临床效果  

Clinical effect of Xiao'er Niuhuang Qingxin powder combined with levetiracetam in the treatment of febrile convulsion in children

作　　者：张素莹 姜虹 ZHANG Suying;JIANG Hong(Weinan Central Hospital,Weinan 714000;Weinan Maternal and Child Health Hospital,Weinan 714000,China)

机构地区：[1]渭南市中心医院,陕西渭南714000 [2]渭南市妇幼保健院,陕西渭南714000

出　　处：《临床医学研究与实践》2023年第10期97-100,共4页Clinical Research and Practice

摘　　要：目的 观察小儿牛黄清心散联合左乙拉西坦治疗小儿热性惊厥的临床效果。方法 选择2019年1月至2021年1月渭南市中心医院收治的75例热性惊厥患儿为研究对象,采用随机数字抽签法将其分为对照组(37例)和观察组(38例)。对照组采用左乙拉西坦治疗,观察组在对照组基础上采用小儿牛黄清心散治疗。比较两组的临床疗效、惊厥反复次数、发热持续时间、血清学指标、不良反应发生情况。结果 观察组的治疗总有效率为92.11%,高于对照组的72.97%,差异具有统计学意义(P<0.05)。治疗前,两组的惊厥反复次数比较,差异无统计学意义(P>0.05);观察组治疗后的惊厥反复次数少于对照组,发热持续时间短于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的神经元特异性烯醇化酶(NSE)、基质金属蛋白酶-9(MMP-9)、胶质纤维酸性蛋白(GFAP)水平比较,差异无统计学意义(P>0.05);治疗后,两组的NSE、MMP-9、GFAP水平均较治疗前降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 小儿牛黄清心散联合左乙拉西坦治疗小儿热性惊厥的效果显著,可减少惊厥反复次数,缩短发热持续时间,降低脑损伤标志物水平,且安全性良好,值得临床推广应用。Objective To observe the clinical effect of Xiao'er Niuhuang Qingxin powder combined with levetiracetam in the treatment of febrile convulsion in children.Methods Seventy-five children with febrile convulsion admitted in Weinan Central Hospital from January 2019 to January 2021 were selected as the research objects and divided into control group(37 cases)and observation group(38 cases)by random number drawing method.The control group was treated with levetiracetam,and the observation group was treated with Xiao'er Niuhuang Qingxin powder on the basis of the control group.The clinical efficacy,number of recurrent convulsions,duration of fever,serological indicators and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 92.11%,which was higher than 72.97%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the number of recurrent convulsions between the two groups(P>0.05);the number of recurrent convulsions in the observation group was less than that in the control group after treatment,the duration of fever was shorter than that in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of neuro-specific enolase(NSE),matrix metalloproteinase-9(MMP-9)and glial fibrillary acidic protein(GFAP)in the two groups(P>0.05);after treatment,the levels of NSE,MMP-9 and GFAP in both groups were lower than those before treatment,those of the observation group were lower than the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Xiao'er Niuhuang Qingxin powder combined with levetiracetam in the treatment of febrile convulsion in children has a significant effect,it can reduce the number of recurrent convulsions,shorten the dur

关 键 词：热性惊厥 小儿 小儿牛黄清心散 左乙拉西坦 惊厥反复次数 血清学指标 

分 类 号：R720.597[医药卫生—急诊医学]