天麻钩藤饮加减方辅助治疗血管源性眩晕症的临床效果  

Clinical effect of modified Tianma Gouteng decoction in adjuvant treatment of vasogenic vertigo

作　　者：张建平 李涛 石敏 王文 刘敏良 路强 ZHANG Jianping;LI Tao;SHI Min;WANG Wen;LIU Minliang;LU Qiang(Internal Medicine Department,Shangluo Traditional Chinese Medicine Hospital,Shangluo 726000,China)

机构地区：[1]商洛市中医医院内科,陕西商洛726000

出　　处：《临床医学研究与实践》2023年第10期101-104,共4页Clinical Research and Practice

摘　　要：目的 探究天麻钩藤饮加减方辅助治疗血管源性眩晕症的临床效果。方法 选择2019年2月至2021年2月在本院就诊的58例血管源性眩晕症患者为研究对象,采用入院序列号随机抽签法将其分为对照组与天麻组,各29例。对照组行甲磺酸倍他司汀治疗,天麻组在对照组基础上加天麻钩藤饮加减方汤剂治疗。比较两组的治疗效果。结果 天麻组的临床疗效优于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的中医证候积分和眩晕障碍量表(DHI)评分比较,差异无统计学意义(P>0.05);治疗后,天麻组的中医证候积分和DHI评分低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的椎动脉(VA)和基底动脉(BA)平均血流速度、α颗粒膜蛋白-140(GMP-140)、D-二聚体/纤维蛋白原(D/F)比较,差异无统计学意义(P>0.05);治疗后,天麻组的VA和BA平均血流速度快于对照组,GMP-140、D/F低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的血管性假血友病因子(vWF)、血栓调节蛋白(TM)、血管细胞黏附分子-1(VCAM-1)水平比较,差异无统计学意义(P>0.05);治疗后,天麻组的vWF、TM、VCAM-1水平低于对照组,差异具有统计学意义(P<0.05)。结论 天麻钩藤饮加减方辅助治疗血管源性眩晕症的效果显著,有利于改善脑血流灌注指标、下调血液高凝指标、促进血管内皮功能修复以及降低炎症指标水平。Objective To explore the clinical effect of modified Tianma Gouteng decoction in adjuvant treatment of vascular vertigo.Methods A total of 58 patients with vasogenic vertigo who were treated in our hospital from February 2019 to February 2021 were selected as the research objects.The patients were divided into control group and Tianma group by random drawing of admission serial number,with 29 cases in each group.The control group was treated with betahistine mesylate,and the Tianma group was treated with modified Tianma Gouteng decoction on the basis of the control group.The therapeutic effects of the two groups were compared.Results The clinical efficacy of the Tianma group was better than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in TCM syndrome score and Dizziness Handicap Inventory(DHI)score between the two groups(P>0.05);after treatment,the TCM syndrome score and DHI score of the Tianma group were lower than those of the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in mean blood flow velocity of vertebral artery(VA)and basilar artery(BA),α-granule membrance protein-140(GMP-140),D-dimer/fibrinogen(D/F)between the two groups(P>0.05);after treatment,the mean blood flow velocity of VA and BA in the Tianma group were faster than those in the control group,the GMP-140 and D/F were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of von Willebrand factor(vWF),thrombomodulin(TM)and vascular cell adhesion molecule-1(VCAM-1)between the two groups(P>0.05);after treatment,the levels of vWF,TM and VCAM-1 in the Tianma group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The modified Tianma Gouteng decoction in adjuvant treatment of vascular vertigo has a significan

关 键 词：血管源性眩晕 天麻钩藤饮加减方 脑血流灌注指标 炎症指标 血管性假血友病因子 血栓调节蛋白 

分 类 号：R255.3[医药卫生—中医内科学]