辅助生殖技术单卵双胎风险因素研究进展  

Research progress on risk factors of monozygotic twins in assisted reproductive technology

作　　者：陈娜[1] 李晶宇 崔琳琳[1] Chen Na;Li Jingyu;Cui Linlin(Center for Reproductive Medicine,the Second Hospital,Cheeloo College of Medicine,Shandong University/Key Laboratory of Reproductive Endocrinology of Ministry of Education,Shandong University/Shandong Key Laboratory of Reproductive Medicine/Shandong Provincial Clinical Research Center for Reproductive Health/National Research Center for Assisted Reproductive Technology and Reproductive Genetics,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学生殖医学研究中心(山东大学第二医院)、生殖内分泌教育部重点实验室、山东省生殖医学重点实验室、山东省生殖健康临床医学研究中心、国家辅助生殖与优生工程技术研究中心,济南250012

出　　处：《中华生殖与避孕杂志》2023年第2期204-208,共5页Chinese Journal of Reproduction and Contraception

摘　　要：自20世纪70年代以来伴随着辅助生殖技术的飞速发展,多胎妊娠发生率明显增加,其所带来的孕期和产后母婴并发症也受到了公众的广泛关注。相关研究提示辅助生殖后代单卵双胎发生率高于自然妊娠,这不仅增加了新生儿相关不良结局的风险,甚至对子代远期健康都存在深远影响。本文对有关辅助生殖子代单卵双胎发生率和诱导排卵、卵子及胚胎操作、体外培养等因素对单卵双胎发生率的影响的相关文献进行了综述,以期深入探讨相关风险因素和可能的机制,为临床减少单卵双胎的发生提供潜在干预靶点。With the rapid development of assisted reproductive technology since the 1970s,the incidence of multiple pregnancies has increased significantly,and the maternal and infant complications during pregnancy and postpartum caused by multiple pregnancies have received extensive public attention.Relevant investigations showed that the rate of monozygotic twins after assisted reproductive technology was higher than that of natural pregnancy,which not only increase the risk of neonatal related adverse outcomes,but also has a far-reaching impact on the long-term health of offspring.In order to understand the related risk factors and potential mechanisms of monozygotic twins after assisted reproductive technology better and provide intervention target for reducing the rate of monozygotic twins in clinic,we sorted out papers about the rate of monozygotic twins in assisted reproductive technology offspring and the effects of factors such as ovulation induction,ovum and embryo manipulation,and in vitro culture on the incidence of monozygotic twins.

关 键 词：双胎 单卵 生殖技术 辅助 受精 体外 囊胚移植 内细胞团 

分 类 号：R714.8[医药卫生—妇产科学]