基于LP_(01)和LP_(11)模式共存的单光纤光镊实现生物细胞多路捕获和操纵  

Single-Fiber Optical Tweezer Based on Coexistence of LP_(01) and LP_(11) Modes for Multiplexed Capture and Manipulation of Biological Cells

作　　者：陈朋[1] 党雨婷 钟慧 姜春雷[1] Chen Peng;Dang Yuting;Zhong Hui;Jiang Chunlei(College of Electrical and Information Engineering,Northeast Petroleum University,Daqing 163318,Heilongjiang,China)

机构地区：[1]东北石油大学电气信息工程学院,黑龙江大庆163318

出　　处：《光学学报》2023年第4期45-53,共9页Acta Optica Sinica

基　　金：黑龙江省自然科学基金联合引导项目(LH2021F008);东北石油大学青年科学基金(2020QNL-13);东北石油大学控制科学与工程团队专项项目(2022TSTD-04)。

摘　　要：提出了一种用于生物细胞多路捕获与操纵的单光纤光镊。基于两种不同模式的光纤错位拼接,实现了LP_(01)和LP_(11)模式共存。该光镊的输出光场具有多个聚焦光斑,能够在多个支路上同时捕获和操纵多个生物细胞。仿真和实验结果表明,该光镊能够在三个支路上同时捕获和操纵多个小球藻细胞,在光镊移动速度约为14μm/s时仍能保持捕获稳定。该光镊结构简单,为生物传感和直接检测生物信号提供了更多可能。Objective Currently,some biophotonic devices or cell-to-cell interactions and communications require the capture of particles,especially multiple particles.Since the invention of optical tweezers in 1986,optical tweezers have become an important tool that is widely used in the manipulation and study of cells,viruses,atoms,colloids,and other particles.Based on conventional optical tweezers,multi-directional alignment of multiple particles is achieved by various methods such as holographic optical tweezers,single beam before helical phase,and optical binding.However,these techniques require bulky optical components,which complicates optical tweezer systems and hinders operational flexibility.To overcome the shortcomings of conventional optical tweezers in capturing multiple particles,researchers have used optical tweezers to capture multiple particles.Some researchers have created multiple optical traps using dual fibers,which enables the capture of multiple particles in two and three dimensions,and they have manipulated,deflected,and stretched multiple cells using two misaligned single-mode fibers.Some researchers have used multicore fibers for two-dimensional optical interference capture of multiple particles and Escherichila coli cells manipulation of multiple particles using photonic crystal mode multiplexing,while others have used fiber traps and photothermal effects to manipulate a large number of particles.However,the optical fiber probes in the above methods with multi-core fibers and photonic crystals are,in general,structurally complex,and difficult to replicate.Focusing on the complex structure of multi-core fiber and photonic crystal fiber probe,this paper proposes a single-fiber optical tweezer structure with two modes being composite.The structure utilizes two different modes of fiber staggered splicing to ensure the LP_(01) and LP_(11) modes coexist in the output optical field,and the two modes of the beam have different focused optical fields to achieve the capture of multiple Chlorella cells in dif

关 键 词：光纤光学 光纤光镊 LP_(01)模式和LP_(11)模式 多路捕获和操纵 生物传感 

分 类 号：Q631[生物学—生物物理学]