鼻黏膜纤毛显微内窥镜光学系统设计  

Design of Optical System for Nasal Mucociliary Microendoscope

作　　者：王鑫[1] 向阳[1] 冯大伟 杨凯明 逄川 陈雷[2,3] Wang Xin;Xiang Yang;Feng Dawei;Yang Kaiming;Pang Chuan;Chen Lei(School of Optoelectronic Engineering,Changchun University of Science and Technology,Changchun 130022,Jilin,China;Department of Otorhinolaryngology Head and Neck Surgery,Chinese PLA General Hospital,Beijing 100039,China;National Clinical Medical Research Center for Otorhinolaryngology,Beijing 100039,China)

机构地区：[1]长春理工大学光电工程学院,吉林长春130022 [2]中国人民解放军总医院耳鼻咽喉头颈外科医学部,北京100039 [3]国家耳鼻咽喉疾病临床医学研究中心,北京100039

出　　处：《光学学报》2023年第4期166-175,共10页Acta Optica Sinica

摘　　要：为了实现从前鼻孔进镜对鼻黏膜表面进行直接显微成像,从而进行无创性观察和测量在体鼻纤毛运动,设计了一种能够分辨鼻纤毛,并且带有30°视向角的变倍硬性显微内窥镜。所设计的硬性内窥镜系统物方数值孔径为0.15,分辨率为272 lp/mm,工作距离为3.00 mm,视向角为30°,物面高度为0.40 mm,系统总长度为205.62 mm,物方口径为4.65 mm,放大倍率为6×~10×。此鼻黏膜纤毛显微内窥镜将可以避免取材造成的纤毛功能损害和受试者痛苦,极大地提高纤毛相关疾病的临床诊断能力,成为助益纤毛领域科研和临床工作的重要突破。Objective Motile cilia of nasal mucosa are widely distributed on the mucosal surface of the human respiratory tract.The defense function of removing mucus and pathogenic particles from the mucosal surface can be realized by swinging regularly in a specific direction.The normal operation of this function is important for maintaining respiratory tract health and human health.The dysfunction of cilia will lead to a series of pathological manifestations,which will seriously affect the health and quality of life of patients.The traditional ciliary motion assessment methods are invasive and cannot reflect the actual motion state of the body.In order to perform direct microscopic imaging of the nasal mucosal surface through the anterior nostril for non-invasive observation and measurement of nasal ciliary movement in vivo,we design a variable-magnification rigid microendoscope with a viewing angle of 30°.The nasal mucosal ciliary microendoscope will avoid the damage to ciliary function and the pain of subjects caused by material extraction,which thus greatly improves the clinical diagnosis ability of cilia-related diseases and becomes an important breakthrough in the scientific research and clinical work in the field of cilia.Methods The design of the optical system of the nasal mucociliary microendoscope is mainly divided into three aspects:optical system design,image quality analysis,and tolerance analysis.The optical system mainly includes an objective lens system,relay system,eyepiece system,and variational adapter system.Firstly,a prism structure is determined so that it has a viewing angle of 30°.On the premise of ensuring the object resolution,we reduce the circumscribed circle diameter of the prism as much as possible and then reduce the object diameter of the entire endoscope.According to the structure of the cilia,we determine the numerical aperture of the objective lens system to provide a sufficient margin to avoid machining errors in the actual processing.According to the principle of pupil matching,the o

关 键 词：医用光学 鼻黏膜纤毛 硬性内窥镜 视向角 变倍 高分辨率 

分 类 号：TH785[机械工程—仪器科学与技术]