妊娠期高血压疾病患者血清指标与妊娠结局的相关性  

Correlation between serum indicators of hypertensive disorder complicating pregnancy and pregnancy outcome

作　　者：朱志敏 赵芳 宋洋洋 赵聪 王红红[1] ZHU Zhimin;ZHAO Fang;SONG Yangyang;ZHAO Cong;WANG Honghong(Baoding Maternal and Child Health Hospital,Hebei Baoding 071000,China)

机构地区：[1]保定市妇幼保健院,河北保定071000

出　　处：《中国妇幼健康研究》2023年第3期29-34,共6页Chinese Journal of Woman and Child Health Research

摘　　要：目的 探讨血清血小板内皮细胞黏附分子-1(PECAM-1)、富亮氨酸重复序列相互作用蛋白(LRRFIP)、人新饱食分子蛋白-1(Nesfatin-1)水平与妊娠期高血压疾病(HDCP)患者妊娠结局的关系。方法 选取2019年1月至2021年6月在保定市妇幼保健院就诊的HDCP患者112例作为HDCP组,另选取同期就诊的正常健康孕妇56例作为对照组,分析血清PECAM-1、LRRFIP、Nesfatin-1与HDCP病情及妊娠结局的关系。结果 与对照组比较,HDCP组的PECAM-1水平较低,LRRFIP、Nesfatin-1水平较高(t值分别为12.699、15.008、7.859,P<0.05)。两两比较发现,PECAM-1水平:重度子痫<子痫前期<妊娠期高血压;LRRFIP、Nesfatin-1水平:重度子痫>子痫前期>妊娠期高血压(P<0.05)。血清PECAM-1与病情程度呈负相关(r=-0.716,P<0.05),LRRFIP、Nesfatin-1与病情程度呈正相关(r值分别为0.773、0.740,P<0.05)。血清PECAM-1、LRRFIP、Nesfatin-1联合评估子痫前期的ROC曲线下面积(AUC)为0.902(95%CI:0.821~0.954),联合评估重度子痫的AUC为0.914(95%CI:0.823~0.967)。与良好妊娠结局患者比较,不良妊娠结局患者的PECAM-1水平较低,LRRFIP、Nesfatin-1水平较高(t值分别为9.937、10.540、5.584,P<0.05);血清PECAM-1与良好妊娠结局呈正相关(r=0.523,P<0.05),而LRRFIP、Nesfatin-1则呈负相关(r值分别为-0.610、-0.587,P<0.05)。结论 血清PECAM-1、LRRFIP、Nesfatin-1水平与HDCP病情密切相关,临床可通过其对HDCP患者妊娠结局进行预测评估,以制定相应干预方案。Objective To investigate the relationships between serum platelet endothelial cell adhesion molecule-1(PECAM-1),leucine-rich repeat flightless-interacting protein(LRRFIP),human new satiety molecular protein-1(Nesfatin-1) levels and pregnancy outcome of hypertensive disorder complicating pregnancy(HDCP).Methods A total of 112 HDCP patients who visited the Baoding Maternal and Child Health Hospital from January 2019 to June 2021 were selected as the HDCP group, and 56 healthy pregnant women during the same period were selected as the control group.The relationships between serum PECAM-1,LRRFIP,Nesfatin-1 and the severity HDCP and pregnancy outcome were analyzed.Results Compared with the control group, the level of serum PECAM-1 in the HDCP group was lower, while the levels of LRRFIP and Nesfatin-1 were higher(t=12.699,15.008 and 7.859,respectively, P<0.05).After comparing in pairs, the order of PECAM-1 level was severe eclampsia < preeclampsia < gestational hypertension, the order of LRRFIP and Nesfatin-1 level was severe eclampsia > preeclampsia > gestational hypertension(P<0.05).Serum PECAM-1 was negatively correlated with disease severity(r=-0.716,P<0.05),while LRRFIP and Nesfatin-1 were positively correlated with disease severity(r=0.773 and 0.740,respectively, P<0.05).The area under the ROC curve(AUC) of serum PECAM-1,LRRFIP and Nesfatin-1 combined to evaluate preeclampsia was 0.902(95%CI:0.821-0.954),and that of the combination to evaluate severe eclampsia was 0.914(95%CI:0.823-0.967).Compared with patients with good pregnancy outcome, the PECAM-1 level was lower and the levels of LRRFIP and Nesfatin-1 were higher in patients with adverse pregnancy outcome(t=9.937,10.540 and 5.584,respectively, P<0.05).Serum PECAM-1 was positively correlated with good pregnancy outcome(r=0.523,P<0.05),while LRRFIP and Nesfatin-1 were negatively correlated with good pregnancy outcome(r=-0.610 and-0.587,respectively, P<0.05).Conclusion Serum levels of PECAM-1,LRRFIP,and Nesfatin-1 are closely related to the severity of HDCP,and

关 键 词：妊娠期高血压疾病 血清指标 病情程度 妊娠结局 

分 类 号：R173[医药卫生—妇幼卫生保健]