儿童重症博卡病毒与呼吸道合胞病毒肺炎的临床比较  

Comparison of clinical characteristics of severe human bocavirus and respiratory syncytial virus pneumonia in children

作　　者：石丽娟 王美娟[2] 吴水燕[2] 刘玉奇[2] 薛健 李莺[2] 柏振江[2] 徐忠[2] SHI Lijuan;WANG Meijuan;WU Shuiyan;LIU Yuqi;XUE Jian;LI Ying;BAI Zhenjiang;XU Zhong(The First People′s Hospital of Changzhou,Jiangsu Changzhou 213000,China;Children′s Hospital of Soochow University,Jiangsu Suzhou 215025,China)

机构地区：[1]常州市第一人民医院,江苏常州213000 [2]苏州大学附属儿童医院,江苏苏州215025

出　　处：《中国妇幼健康研究》2023年第3期81-86,共6页Chinese Journal of Woman and Child Health Research

摘　　要：目的 通过对比分析儿童重症博卡病毒(HBoV)肺炎和最常见的呼吸道合胞病毒(RSV)肺炎,以更好地了解儿童重症HBoV肺炎的临床特征,指导临床医生鉴别诊治。方法 回顾性分析了2017年1月至2019年12月苏州大学附属儿童医院儿童重症医学科(PICU)的42例重症HBoV肺炎及110例重症RSV肺炎患儿的临床资料,比较两种肺炎的发病年龄、季节分布及临床特征等。结果 重症HBoV肺炎和重症RSV肺炎的发生率分别为1.93%(42/2 178)和2.61%(110/4 218);重症HBoV肺炎以1~3岁幼儿高发(64.29%),中位年龄在1.33(1.00,1.89)岁,显著大于重症RSV肺炎的中位年龄0.17(0.12,0.32)岁(Z=-7.765,P<0.05);重症HBoV肺炎患儿伴发热的比例为30.95%(13/42),显著高于重症RSV肺炎的11.81%(13/110)(χ^(2)=7.848,P<0.05);重症HBoV肺炎患儿需要机械通气的比例为26.19%(11/42),显著高于重症RSV肺炎的5.45%(6/110)(χ^(2)=13.157,P<0.05)。7.14%(3/42)的重症HBoV肺炎患儿可发生塑型性支气管炎。结论 重症HBoV肺炎多发生于1~3岁幼儿,更易出现发热症状。此外,重症HBoV肺炎可发生塑型性支气管炎,且需要机械通气的可能性更大。Objective By comparing and analyzing severe human bocavirus(HBoV) and common respiratory syncytial virus(RSV) pneumonia in children, to understand the clinical characteristics of HBoV pneumonia in children, and guide clinicians to better distinguish, diagnose and treat.Methods The clinical data of 42 children with severe HBoV pneumonia and 110 children with severe RSV pneumonia from the pediatric intensive care unit(PICU) of Children′s Hospital of Soochow University from January 2017 to December 2019 were retrospectively analyzed.The age, season and clinical characteristics of the two types of pneumonia were compared.Results The incidences of severe HBoV and RSV pneumonia were 1.93%(42/2178) and 2.61%(110/4218),respectively.The incidence of severe HBoV pneumonia was high in children aged 1~3 years old, and the median age of severe HBoV pneumonia group was 1.33(1.00-1.89) years old, which was significantly higher than that of the severe RSV pneumonia group with 0.17(0.12-0.32) years old(Z=-7.765,P<0.05).The proportion of children with fever in the severe HBoV pneumonia group was 30.95%(13/42),which was significantly higher than that of the severe RSV pneumonia group with 11.81%(13/110)(χ^(2)=7.848,P<0.05).The proportion of children who need mechanical ventilation in the severe HBoV pneumonia group was 26.19%(11/42),which was significantly higher than that of the severe RSV pneumonia group with 5.45%(6/110)(χ^(2)=13.157,P<0.05).7.14%(3/42) of children with severe HBoV pneumonia could develop plastic bronchitis.Conclusion Severe HBoV pneumonia is more likely to occur in children aged 1-3 years old.In addition, severe HBoV pneumonia may develop to plastic bronchitis, and is more likely to require mechanical ventilation.

关 键 词：人类博卡病毒 重症肺炎 儿童 临床特征 

分 类 号：R179[医药卫生—妇幼卫生保健]