社区居民控制高血压饮食模式与高尿酸血症的关联研究  

Study on association between the Dietary Approaches to Stop Hypertension(DASH)diet and hyperuricemia among community residents

作　　者：易康祺 崔淑衡 郁雨婷 向宇 朱俊洁 童鑫 赵琦[1] 吴毅凌[2] 姜永根[2] 赵根明[1] YI Kang-qi;CUI Shu-heng;YU Yu-ting;XIANG Yu;ZHU Jun-jie;TONG Xin;ZHAO Qi;WU Yi-ling;JIANC Yong-gen;ZHAO Gen-ming(Department of Epidemiology,School of Public Health,Fudan University/Key Laboratory of Public Health Safety of Ministry of Education,Shanghai 200032,China;不详)

机构地区：[1]复旦大学公共卫生学院流行病学教研室公共卫生安全教育部重点实验室,上海200032 [2]上海市松江区疾病预防控制中心

出　　处：《中国慢性病预防与控制》2023年第1期26-30,共5页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：国家重点研发计划精准医学重点专项(2017YFC0907000);上海市加强公共卫生体系建设三年行动计划(2020-2022年)公共卫生重点学科建设项目(GWV-10.1-XK16)。

摘　　要：目的探讨控制高血压饮食模式(DASH)与高尿酸血症患病的关联,为高尿酸血症的饮食防控提供科学依据。方法于2016年4月至2017年10月,采用多阶段分层整群抽样法抽取上海市松江区36404名20~74岁社区居民为研究对象,进行问卷调查、体格检查和生化指标检测。排除关键变量缺失的对象后,共纳入32766名研究对象,根据DASH评分五分位数将研究对象分为Q1~Q55组。采用R 4.0.3软件进行Pearsonχ^(2)检验,采用多因素logistic回归分析DASH饮食模式与高尿酸血症患病的关联。结果检出高尿酸血症患者4456例,粗患病率为13.60%,标化患病率为11.80%。多因素logistic回归分析结果显示,调整混杂因素后,与Q1组比较,Q2组(OR=0.86),Q3组(OR=0.82),Q4组(OR=0.84)和Q5组(OR=0.74)与高尿酸血症患病低风险相关,均有统计学意义(P<0.01)。在≥4个心血管代谢性共病的人群中进一步分析,与Q1组比较,Q3组(OR=0.66),Q4组(OR=0.60)和Q5组(OR=0.60)与高尿酸血症患病低风险相关(P<0.01)。结论DASH饮食模式对降低高尿酸血症患病风险具有积极作用,这种作用在具有较多心血管代谢性共病的人群中更强。Objective To explore the association between the Dietary Approaches to stop Hypertension(DASH)diet and hyperuricemia,and provide scientific basis for diet prevention and intervention strategy.Methods A total of 36404 community residents aged20-74 in Songjiang District,Shanghai were recruited by a multi-stage stratified cluster sampling method from April 2016 to October 2017,who completed baseline questionnaires,physical examinations,and clinical biochemical tests.The study finally included 32766 participants after excluding the participants with missing key variables.Each participant was assigned a DASH dietary pattern score and then divided into Q1-Q5five groups according to the quintiles of the score,where a higher group indicates a higher compliance with the DASH diet.R 4.0.3 software was used for Pearsonχ^(2)test.Multivariate logistic regression was used to analyze the association between DASH diet and hyperuricemia.Results A total of 4456 patients with hyperuricemia were detected,while the crude and standardized prevalence of hyperuricemia was 13.60%and 11.80%,respectively.Multivariate logistic regression analysis showed that after adjusting for confounding factors,as compared with the Q1group,the Q2-Q5groups were associated with lower risk of hyperuricemia(the OR values were 0.86,0.82,0.84 and 0.74,P<0.01),respectively.Further stratified analysis showed that the same association between the DASH diet and hyperuricemia,as compared with the Q1group,the OR values of the Q3-Q5groups were 0.66,0.60 and 0.60,P<0.01.Conclusion The DASH diet has a positive effect on reducing the risk of having hyperuricemia,especially in people with multiple cardiometabolic risk factors.

关 键 词：控制高血压饮食模式 高尿酸血症 横断面研究 

分 类 号：R589.7[医药卫生—内分泌]