An Electrocatalytic Strategy for Dehydrogenative[4+2]Cycloaddition over a Cobalt-Based Catalyst  

作　　者：Xiaomeng Xue Ye Wang Lina Zhou Ruixiang Ge Jiangrong Yang Xianggui Kong Ming Xu Zhenhua Li Lina Ma Haohong Duan 

机构地区：[1]State Key Laboratory of Chemical Resource Engineering,Beijing University of Chemical Technology,Beijing 100029,China [2]Department of Chemistry,Tsinghua University,Beijing 100084,China [3]State Key Laboratory of Catalytic Materials and Reaction Engineering,Research Institute of Petroleum Processing,SiNOPEC,Beijing 100083,China

出　　处：《Chinese Journal of Chemistry》2022年第23期2741-2746,共6页中国化学（英文版）

基　　金：Financial support was provided by the National Natural Science Foundation of China(21978147,21935001,22090030,22105015);the China Postdoctoral Science Foundation(2019M660421);State Key Laboratory of Catalytic Materials and Reaction Engineering(RIPP,SINOPEC).

摘　　要：Exploring the anodic reaction to substitute conventional oxygen evolution reaction(OER)for the synthesis of complex pharmaceutical molecules is highly attractive.Here,we report an electrocatalytic strategy for dehydrogenative[4+2]cycloaddition of N,N-dialkylanilines with maleimides via dual functionalization of both C(sp3)-H and C(sp2)-H bonds,by using an electrochemically activated cobalt carbonate hydroxide hydrate supported on carbon cloth(CCHH-A/CC),affording various tetrahydroquinolines with high yields.This electrochemical transformation proceeds with high activity and stability,as well as good substrate compatibility.Mechanism study shows thatα-aminoalkyl radical exists in the electrooxidation reaction.This strategy shows significant potential for the synthesis of valuable chemicals by using an electrocatalytic strategy.

关 键 词：CYCLOADDITION C-H activation DEHYDROGENATION Eletrooxidation reactions Cobalt-based catalyst 

分 类 号：O62[理学—有机化学]