cis-Clerodane Diterpenoids with Structural Diversity and Anti-inflammatory Activity from Tinospora crispa  

作　　者：Jin-Qiu You Yi-Nan Liu Jun-Su Zhou Xin-Yu Sun Chun Lei Qing Mu Jing-Ya Li Ai-Jun Hou 

机构地区：[1]School of Pharmacy,Fudan University,Shanghai,201203 China [2]School of Pharmacy,Shanghai Jiao Tong University,Shanghai,200240 China [3]Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203 China

出　　处：《Chinese Journal of Chemistry》2022年第24期2882-2892,I0002,共12页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.22277074).

摘　　要：Twelve new cis-clerodane diterpenoids, designated as crispinoids A—L (1—12), together with three known analogues (13—15), were isolated from Tinospora crispa. Their structures were fully assigned by comprehensive spectroscopic techniques, single-crystal X-ray diffraction experiments, and electronic circular dichroism (ECD) analyses. The isolated clerodanes displayed diverse heterocyclic frameworks including 6/6/6-, 6/5/6/6-, 6/6/5-, 6/6-, and 6/5/6-fused ring systems. Some of the isolates showed ATP-citrate lyase (ACLY) and nuclear factor kappa B (NF-κB) pathway inhibition. The NF-κB inhibitors further suppressed the lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 cells.

关 键 词：Natural products Structure elucidation Tinospora crispa ATP-citrate lyase Nuclear factor kappa B 

分 类 号：O62[理学—有机化学]