血浆致动脉硬化指数与铁路工人颈动脉斑块的相关性研究  

Association between the atherogenic index of plasma and carotid artery plaque among railway workers

作　　者：魏海英[1] 王梓航 曾红莲[1] 唐蕾[1] 杨波[1] 李茂 杨淑娟 潘佳 WEI Hai-ying;WANG Zi-hang;ZENG Hong-lian;TANG Lei;YANG Bo;LI Mao;YANG Shu-juan;PAN Jia(Health Management Center,The Affiliated Hospital of Chengdu University,Chengdu,Sichuan 610081,China;不详)

机构地区：[1]成都大学附属医院健康管理中心,四川成都610081 [2]四川大学华西公共卫生学院/华西第四医院

出　　处：《现代预防医学》2023年第5期809-812,819,共5页Modern Preventive Medicine

基　　金：四川省科技厅区域创新合作(2021QYCX0083);成都市科技局重点研发支撑计划(2021-YF05-00886-SN);四川大学-达州校市战略合作专项(2020CDDZ-26,2020CDDZ-26-SCU);成都大学校青年基金项目(2018XZB13);成都大学附属医院院级科研课题(2020YYZ42)。

摘　　要：目的 研究铁路工人中血浆致动脉硬化指数(AIP)与颈动脉斑块的相关性。方法 收集中国西南地区3 169名铁路工人的数据,根据AIP四分位数分为四组(Q1、Q2、Q3、Q4),通过颈动脉多普勒超声评估颈动脉斑块。采用多因素logistic回归分析AIP和颈动脉斑块之间的关联。结果 与AIP最低四分位数(Q1)的工人相比,高AIP四分位数(Q2、Q3、Q4)的工人颈动脉斑块发生风险较高,颈动脉斑块发生率Q1、Q2、Q3、Q4分别为12.50%、14.65%、19.55%、17.80%。当AIP指数作为连续型变量时,回归模型显示,AIP与发生颈动脉斑块的风险呈正相关(OR=1.46,95%CI:1.06~1.99)。随着AIP四分位数的增加,发生颈动脉斑块的风险有所增加,与Q1相比,Q2:OR=1.18(95%CI:0.88~1.59),Q3:OR=1.60(95%CI:1.20~2.15),Q4:OR=1.38(95%CI:1.01~1.88)。结论 AIP与铁路工人发生颈动脉斑块有关,高AIP水平的工人发生颈动脉斑块风险更大。Objective To explore the association between the atherogenic index of plasma(AIP)and carotid artery plaque among railway workers.Methods Medical examination data were collected from 3169 railway workers in southwest China.Participants were divided into four groups(Q1,Q2,Q3,and Q4)according to AIP quartiles,and carotid artery plaque was assessed by carotid Doppler ultrasound.Logistic regression was used to analyze the association between the AIP and carotid artery plaque.Results Compared with workers in the lowest AIP quartile(Q1:12.5%),the prevalence of carotid artery plaque was higher in workers in high AIP quartiles(Q2:14.65%,Q3:19.55%,and Q4:17.80%,respectively).When the AIP index was used as a continuous variable,the logistic regression model showed that AIP was positively associated with the risk of developing carotid artery plaque(OR=1.46,95%CI:1.06-1.99).Compared with Q1,the risk of carotid artery plaque increased with increasing AIP quartiles:(Q2:OR=1.18,95%CI:0.88-1.59,Q3:OR=1.60,95%CI:1.20-2.15,and Q4:OR=1.38,95%CI:1.01-1.88,respectively).Conclusion The AIP is associated with carotid artery plaque in railway workers,especially among workers with high AIP quartiles.

关 键 词：血浆致动脉硬化指数 AIP 颈动脉斑块 铁路工人 

分 类 号：R514.4[医药卫生—内科学]