清瘟败毒饮截断病毒性肺炎“气-营”传变的可能机制分析:Th1/Th2漂移  

Analysis of the Possible Mechanism of Qingwen Baidu Decoction in Intercepting the"Qi-Ying"Transmission of Viral Pneumonia:Th1/Th2 Drift

作　　者：纪少秀 万亭君 文莉 冯全生[1] JI Shao-xiu;WAN Ting-jun;WEN Li;FENG Quan-sheng(College of Basic Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu,610075;Infectious Disease Department,Traditional Chinese Medicine Hospital of Yinchuan,Yinchuan,750001)

机构地区：[1]成都中医药大学基础医学院,成都610075 [2]银川市中医医院感染科,银川750001

出　　处：《中国中西医结合杂志》2023年第1期102-106,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家中医药管理局中医药传承与创新“百千万”人才工程项目(No.003109011004);四川省科技创新苗子工程资助项目(No.2019049)。

摘　　要：卫气营血理论概括了外感温热病的一般病机演变规律,特别是在肺系感染性疾病的辨治中发挥了重要作用。现代研究表明,Th1型细胞因子主要参与细胞免疫,Th2型细胞因子主要参与体液免疫,Th1/Th2漂移是免疫调节的中心环节。病毒性肺炎早期(卫气分)以Th1型细胞因子为主,当疾病进展由卫气分向营血分传变,Th1/Th2呈下降趋势,在疾病后期(营血分)则以Th2型细胞因子为主。因此,Th1/Th2漂移引起的细胞因子失衡可能是病毒性肺炎卫气营血传变的微观病机演变,温病名方清瘟败毒饮善治气分淫热之疫,常用于病毒性肺炎气分证的治疗,故本文以调节Th1/Th2漂移为治疗靶点,探讨清瘟败毒饮截断气营传变的内在机制。The Wei-Qi-Ying-Xue theory generalizes the general pathogenesis evolution of exogenous warm diseases.Especially,it plays an important role in the treatment of pulmonary infectious diseases.Modern studies have shown that Th1 cytokines are mainly involved in cellular immunity,while Th2 cytokines mainly participate in humoral immunity,and Th1/Th2 drift is the key factor of immune regulation.Th1 cytokines are predominant in the early stage(Wei-Qi stage)of viral pneumonia.When the disease progresse from WeiQi stage to Ying-Xue stage,Th1/Th2 showing a downward trend,and Th2 cytokines are dominant in the late stage of the disease(Ying-Xue stage).Therefore,the imbalance of cytokines caused by Th1/Th2 drift may be the microscopic pathogenesis evolution of Wei-Qi-Ying-Xue transmission in viral pneumonia.Qingwen Baidu Decoction,a famous prescription for warm diseases,have an advantage in treating the heat syndrome in Qi stage,which is often used in treating syndrome in Qi stage.Hence,this paper takes regulating Th1/Th2 drift as the treatment target,and discusses the potential mechanism of Qingwen Baidu Decoction intercepting the transmission of Wei-Qi-Ying-Xue.

关 键 词：清瘟败毒饮 截断治疗 气营传变 TH1/TH2漂移 

分 类 号：R285[医药卫生—中药学]