几种常见双特异性抗体研究进展  

Research progress in and applications of bispecific antibodies

作　　者：郭家正 王荣 陆健昇 杨志新 GUO Jia-zheng;WANG Rong;LU Jian-sheng;YANG Zhi-xin(Institute of BiotechnologyAcademy of Military Medical Sciences,Academy of Military Sciences,Beijing 100071,China)

机构地区：[1]军事科学院军事医学研究院生物工程研究所,北京100071

出　　处：《军事医学》2023年第2期146-149,共4页Military Medical Sciences

基　　金：国家科技部新冠肺炎应急项目(2020YFC0841400)。

摘　　要：随着基因编辑等生物技术进步,双特异性抗体研究和应用有了极大发展。双特异性抗体具有2个抗原结合区,可同时靶向2个不同抗原表位,在临床治疗方面具有重大意义,广泛应用于癌症治疗和炎症反应。但双特异性抗体构建方式并不固定,且每种结构各具特色。该文简要介绍了几种常见双特异性抗体构建方式、构建原理及其应用进展。With the advances of biotechnology such as gene editing,great progress has been made in the study and application of bispecific antibodies. Bispecific antibodies have two antigen binding regions and can target two different epitopes at the same time. They are of great significance in clinical treatment and are widely used in cancer treatment and inflammation. However,the construction methods of bispecific antibodies are subject to change,and each structure has its own characteristics. This article outlines the construction methods,construction principles and applications related to a number of common bispecific antibodies.

关 键 词：抗体 双特异性 scFv-IgG DVD-IgG 构建方式 构建原理 临床应用 

分 类 号：Q81[生物学—生物工程]