气郁理论与非酒精性脂肪性肝病胰岛素抵抗关联探析  

The Relationship Between Qi Stagnation Theory and Insulin Resistance in Nonalcoholic Fatty Liver Disease

作　　者：吕一航 罗容 李丰源 赵微 王维 Lv Yihang;Luo Rong;Li Fengyuan;Zhao Wei;Wang Wei(School of Basic Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China)

机构地区：[1]云南中医药大学基础医学院,云南昆明650500

出　　处：《亚太传统医药》2023年第3期249-251,共3页Asia-Pacific Traditional Medicine

基　　金：国家自然科学基金—地区科学基金:从NIK与PPARα互作调控肝脏脂质代谢稳态角度研究去脂软肝方治疗非酒精性脂肪肝分子机制(81960816)。

摘　　要：近年来,由于人们生活方式和饮食习惯的改变,非酒精性脂肪性肝病(NAFLD)的发病率逐年上升。胰岛素抵抗(IR)是非酒精性脂肪性肝病的核心发病机制之一,可引起糖脂代谢紊乱、脂质蓄积肝脏等。中医理论认为,气机失调是代谢失常的重要原因,其中气郁引起的输布不畅、肝失疏泄是肝病发生的常见病机。通过梳理气郁与非酒精性脂肪性肝病进展的相关性,探讨气郁和胰岛素抵抗的内在关联。In recent years, the incidence of nonalcoholic fatty liver disease(NAFLD) has been increasing year by year due to changes in people’s lifestyle and dietary habits. Insulin resistance(IR) is one of the core pathogenesis of nonalcoholic fatty liver disease, which can cause disorder of glucolipid metabolism and lipid accumulation in the liver. According to the theory of traditional Chinese medicine, the imbalance of Qi movement is an important cause of metabolic disorder, among which the poor distribution caused by Qi stagnation and the loss of liver drainage are the common pathogenesis of liver disease. The author combed the correlation between Qi stagnation and the progression of nonalcoholic fatty liver disease, and explored the internal correlation between Qi stagnation and insulin resistance.

关 键 词：非酒精性脂肪性肝病 气郁 胰岛素抵抗 气机失调 代谢失常 关联性研究 

分 类 号：R256.4[医药卫生—中医内科学]