慢性肾炎蛋白尿患者治疗中缬沙坦联合百令胶囊方案的应用价值  

Application value of valsartan combined with Bailing capsule in the treatment of proteinuria patients with chronic nephritis

作　　者：吕小草 吕改 曹提 鲁冰[1] Xiao-Cao LYU;Gai LYU;Ti CAO;Bing LU(Department of Nephrology,Nanyang Central Hospital,Nanyang 473000,Henan Province,China)

机构地区：[1]南阳市中心医院肾内科,河南南阳473000

出　　处：《数理医药学杂志》2023年第3期208-214,共7页Journal of Mathematical Medicine

基　　金：南阳市科技发展计划项目(2018KJGG108)。

摘　　要：目的分析慢性肾炎蛋白尿患者治疗中缬沙坦联合百令胶囊方案的应用价值。方法将2021年2月至2022年2月南阳市中心医院收治的86例慢性肾炎蛋白尿患者随机分为观察组(n=43)和对照组(n=43)。观察组使用缬沙坦+百令胶囊治疗,对照组使用缬沙坦治疗。对比两组患者临床疗效、24 h蛋白尿定量水平变化、肾功能、血清指标以及不良反应发生率。结果观察组治疗有效率显著高于对照组(95.35%vs.81.40%,P=0.044)。治疗后2个月,观察组平均24 h蛋白尿定量水平、尿素氮(BUN)、血肌酐(SCr)及内生肌酐清除率(CCr)显著低于对照组;而免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)均高于对照组。治疗后,两组患者生命体征平稳,均未见显著过敏反应及其他不良反应。结论针对慢性肾炎蛋白尿患者实施缬沙坦结合百令胶囊进行治疗,可能对改善患者肾功能、调节血清免疫系统具有一定的积极性。Objective To analyze the application value of valsartan combined with bailing capsule in the treatment of proteinuria patients with chronic nephritis.Methods 86 patients with chronic glomerulonephritis proteinuria admitted to Nanyang Central Hospital from February 2021 to February 2022 were randomly divided into observation group(n=43)and control group(n=43).The control group was treated with valsartan,the observation group was treated with valsartan+Bailing capsule,and the clinical efficacy,changes in 24-hour proteinuria quantitative level,renal function,serum indicators and adverse reaction rate of the two groups were compared.Results There was a statistically significant difference in the clinical efficacy between observation group and control group(95.35%vs.81.40%,P=0.044).Two months after treatment,the level of average 24-hour proteinuria quantitative,BUN,SCr and CCr in the observation group were lower than those in the control group.IgA,IgM,IgG in the observation group were statistically higher than those in the control group.After treatment,the vital signs of patients in both groups were stable,and there were no significant allergic reactions and other adverse reactions.Conclusion The treatment of valsartan combined with Bailing capsule for proteinuria in patients with chronic nephritis probably has a positive effect on improving the renal function and regulating the serum immune system.

关 键 词：慢性肾炎 缬沙坦 百令胶囊 蛋白尿 肾功能 不良反应 

分 类 号：R692.3[医药卫生—泌尿科学]