慢性子宫内膜炎患者血清性激素水平与不孕不育的关系  

Relationship between serum sex hormone level and infertility in patients with chronic endometritis

作　　者：黄卓华[1,2] 黄涛 雷嘉[1,2] 罗业琳 江布英[1,2] 郭梓耘 李秀青 HUANG Zhuohua;HUANG Tao;LEI Jia;LUO Yelin;JIANG Buying;GUO Ziyun;LI Xiuqing(Department of Gynecology,Wuzhou Red Cross Hospital,Wuzhou 543000,Guangxi,China;Department of Gynecology,Jiaxing First Hospital,Jiaxing 314001,Zhejiang,China)

机构地区：[1]梧州市红十字会医院妇科,广西梧州543000 [2]嘉兴市第一医院妇科,浙江嘉兴314001

出　　处：《中国性科学》2023年第3期93-97,共5页Chinese Journal of Human Sexuality

摘　　要：目的探讨慢性子宫内膜炎患者血清性激素水平与不孕不育的关系。方法选取2019年1月至2022年3月梧州市红十字会医院妇科收治的100例慢性子宫内膜炎患者作为研究对象。随机分为慢性子宫内膜炎组(n=72)和慢性子宫内膜炎合并不孕不育组(n=28)。收集比较两组基线资料,以及血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_(2))、睾酮(T)、孕酮(P)水平,多因素分析明确慢性子宫内膜炎患者并不孕不育的危险因素。结果慢性子宫内膜炎合并不孕不育组月经经期长于慢性子宫内膜炎组,有人流史、分娩史的患者占比及LH、T、P水平均高于慢性子宫内膜炎组,FSH、E_(2)水平低于慢性子宫内膜炎组(P<0.05)。受试者工作特征曲线分析结果显示,月经经期、LH、FSH、E_(2)、T、P水平均能预测慢性子宫内膜炎患者不孕不育,曲线下面积分别为0.670、0.824、0.835、0.676、0.694、0.766(P<0.05)。多因素分析结果显示,月经经期≥5.470d、有人流史、分娩史、LH≥5.835mIU/mL、FSH<5.345mIU/mL、E_(2)<59.615pg/mL、T≥0.345ng/mL、P≥0.510ng/mL为慢性子宫内膜炎患者不孕不育的危险因素(P<0.05)。结论慢性子宫内膜炎患者血清LH、FSH、E_(2)、T、P水平与女性不孕不育的关系密切。Objective To investigate the relationship between serum luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E_(2)),testosterone(T),progesterone(P)levels and infertility in patients with chronic endometritis.Methods 100 patients with chronic endometritis admitted to the Department of Gynecology of Wuzhou Red Cross Hospital from January 2019 to March 2022 were selected as research objects.They were randomly divided into chronic endometritis group(n=72)and chronic endometritis group with infertility group(n=28).The basic data and serum LH,FSH,E_(2),T,P levels of the two groups were collected and compared,and the risk factors of infertility in patients with chronic endometritis were determined by multivariate analysis.Results The menstrual period of patients in chronic endometritis with infertility group was longer than that of patients with chronic endometritis group,the proportion of patients with history of abortion and delivery,LH,T,P levels were all higher than chronic endometritis group,and FSH,E_(2) levels were lower than those of patients with chronic endometritis group(P<0.05).ROC analysis showed that menstrual period,LH,FSH,E_(2),T,P levels could predict infertility in patients with chronic endometritis,and the area under the curve were 0.670,0.824,0.835,0.676,0.694,0.766(P<0.05).Multivariate analysis showed that menstrual period≥5.470 d,history of abortion,history of childbirth,LH≥5.835 mIU/mL,FSH<5.345 mIU/mL,E_(2)<59.615 pg/mL,T≥0.345 ng/mL,P≥0.510 ng/mL were risk factors for infertility in patients with chronic endometritis(P<0.05).Conclusions Serum LH,FSH,E_(2),T and P levels in patients with chronic endometritis are closely related to female infertility.

关 键 词：慢性子宫内膜炎 黄体生成素 卵泡生成素 雌二醇 睾酮 孕酮 不孕不育 

分 类 号：R711[医药卫生—妇产科学]