右归丸联合丝裂霉素C对经尿道前列腺电切术治疗良性前列腺增生患者术后性功能和尿流动力学的影响  

Effects of Yougui pill combined with mitomycin C on sexual function and urodynamics in patients with benign prostatic hyperplasia after transurethral resection of prostate

作　　者：南宁[1] 张慧[1] 陈琦[1] NAN Ning;ZHANG Hui;CHEN Qi(Department of Urology,the Second Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710004,Shaanxi,China)

机构地区：[1]西安交通大学第二附属医院泌尿外科,西安710004

出　　处：《中国性科学》2023年第3期130-133,共4页Chinese Journal of Human Sexuality

基　　金：陕西省重点研究计划(2018ZDCXL-SF-01-02-02)。

摘　　要：目的探讨右归丸联合丝裂霉素C(MMC)对经尿道前列腺电切术(TURP)治疗良性前列腺增生(BPH)患者术后性功能和尿流动力学的影响。方法选取2018年6月至2021年6月西安交通大学第二附属医院诊治的88例行TURP治疗的BPH患者作为研究对象。采用随机数字表法分为观察组和对照组,各44例。对照组术后给予MMC治疗,观察组术后给予MMC联合右归丸治疗,均持续治疗8个月。比较两组治疗前后中医证候积分、国际前列腺症状评分法(IPSS)评分、国际勃起功能障碍指数-5(IIEF-5)评分、生活质量(QoL)评分,以及男性性功能问卷(MSF-4)评分变化,比较两组治疗前后尿流动力学指标[最大尿流量(Q max)、最大逼尿肌压力(MDP)、强烈尿感容量(SD)、剩余尿量(PVR)、膀胱顺应性(BC)]变化,统计两组手术并发症发生情况。结果治疗后,观察组中医证候积分、IPSS、QoL评分低于对照组,IIEF-5、MSF-4评分高于对照组,PVR水平低于对照组,Q max、SD、MDP、BC水平高于对照组,差异具有统计意义(P<0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论右归丸联合MMC应用于BPH患者TURP术后治疗,可显著改善患者性功能与尿流动力学,提高手术治疗效果。Objective To explore the effects of Yougui pill combined with mitomycin C(MMC)on sexual function and urodynamics in patients with benign prostatic hyperplasia(BPH)after transurethral resection of prostate(TURP).Methods A total of 88 patients with BPH undergoing TURP in the Second Affiliated Hospital of Xi′an Jiaotong University were enrolled as the research objects between June 2018 and June 2021.According to random number table method,they were divided into observation group and control group,44 cases in each group.After surgery,control group was treated with MMC,while observation group was additionally treated with Yougui pill.All were continuously treated for 8 months.The changes in scores of traditional Chinese medicine(TCM)syndromes,international prostate symptom score(IPSS),scores of international index of erectile function-5(IIEF-5),quality of life(QoL)and male sexual function 4 Items(MSF-4),and levels of urodynamics indexes[maximum flow rate(Q max),maximal detrusor pressure(MDP),strong urine sensation volume(SD),postvoid residual(PVR),bladder compliance(BC)]before and after treatment were compared between the two groups.The occurrence of surgical complications in the two groups was observed and compared.Results After treatment,scores of TCM syndromes,IPSS and QoL in observation group were lower than those in control group,IIEF-5 and MSF-4 scores was higher than that in control group,PVR level was lower than that in control group,Q max,SD,MDP and BC levels were higher than those in control group(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusions Yougui pill combined with MMC can significantly improve sexual function and urodynamics,and improve surgical effect in BPH patients after TURP.

关 键 词：良性前列腺增生 经尿道前列腺电切术 性功能障碍 丝裂霉素C 右归丸 

分 类 号：R697[医药卫生—泌尿科学]