高海拔地区围绝经期女性性激素水平与血红蛋白的相关性  

Study of correlation between estrogen level and polycythemia in perimenopausal women in plateau area

作　　者：王丽萍 吕发贞 马国芳 陈玉芬 范晓红 穆兰芳 WANG Li-ping;LYU Fa-zhen;MA Guo-fang;CHEN Yu-fen;FAN Xiao-hong;MU Lan-fang(Department of Obstetrics and Gunecology,Qinghai Women and Children's Hospital,Xining,Qinghai 810007,China)

机构地区：[1]青海省妇女儿童医院妇产科,青海西宁810007

出　　处：《中国妇幼保健》2023年第6期1136-1139,共4页Maternal and Child Health Care of China

基　　金：青海省卫健委资助项目(2018-wjzd-06)。

摘　　要：目的 探讨4 000米以上高海拔地区围绝经期女性性激素水平与血红蛋白(Hb)的相关性。方法 以2018年1月—2020年1月在青海省玉树州治多县(平均海拔4 500米)人民医院正常体检的围绝经期女性为研究对象,将符合研究要求的195名受试者分为40岁~、50岁~、60岁~3个年龄组,采用希森美康XN-1000型自动血球分析仪检测血常规,记录红细胞计数(RBC)、Hb及红细胞比容(Hct);使用COBAS 8000型全自动化学发光分析仪和配套试剂检测血清孕激素(P)、雌二醇(E2)、卵泡刺激素(FSH)及黄体生成素(LH)水平;分析E2、FSH水平与Hb和Hct的相关性。结果 围绝经期女性平均收缩压为(118.48±12.70)mm Hg,舒张压为(81.50±6.97) mm Hg,随着年龄的增加,血压升高,不同年龄围绝经期女性收缩压和舒张压比较,差异均有统计学意义(F=51.637、15.995,均P<0.05)。围绝经期女性平均Hb为(142.74±20.29)g/L,随着年龄的增加,Hb水平升高,不同年龄围绝经期女性Hb水平比较,差异有统计学意义(F=16.659,P<0.05)。围绝经期女性平均Hct为(40.98±8.34)%,不同年龄围绝经期女性Hct水平比较,差异有统计学意义(F=22.998,P<0.05)。不同年龄围绝经期女性RBC水平比较,差异无统计学意义(F=2.141,P>0.05)。随着年龄增加围绝经期女性Hb>150 g/L者增加,40岁~组为5.13%,50岁~组24.71%,60岁~组56.25%,3组间比较,差异有统计学意义(χ^(2)=34.028,P<0.05)。不同年龄围绝经期女性Hct≥45%比例比较,差异均有统计学意义(χ^(2)=27.615,P<0.05)。受试者中Hb≥190 g/L者,40岁~组1例(1.28%),50岁~组3例(3.53%);60岁~组3例(9.38%)。围绝经期女性平均E2水平为(8.76±1.33)pg/ml,平均FSH水平为(71.57±8.33)U/L,平均P水平为(1.48±0.42)nmol/L,平均LH水平为(46.59±3.02)U/L。随着年龄的增加,围绝经期女性E2水平逐渐降低,不同年龄围绝经期女性E2水平比较,差异有统计学意义(F=66.872,P<0.05)。不同年龄围绝经期女性FSH水平比较,差异有统计学�Objective To demonstrate the correlation between hormone level and haemoglobin(Hb) ratio of perimenopausal women in plateau above 4000 meters.Methods From January 2018 to January 2020,195 perimenopausal women in the people’s Hospital of Zhiduo County, Yushu Prefecture, Qinghai Province(with an average altitude of 4 500 meters) were selected as observation objects.These samples were divided into three groups categorized by ages(40 years-,50 years-,60 years-).Then use the automatic hematology analyzerSysmex XN-1000 to analyze blood routine and record the value of the red blood cell count(RBC),hemoglobin(Hb),hematocrit(Hct).Also, use automatic chemiluminescence analyzer COBAS 8000 with supplementary reagent test serum progesterone(P),Estradiol(E2),follicle stimulating hormone(FSH) and prolactin(LH) level.The correlations among E2,FSH level, Hb and Hct was also analyzed.Results The average systolic blood pressure of perimenopausal women was(118.48±12.70) mm Hg, and diastolic blood pressure was(81.50±6.97) mm Hg.Blood pressure increases with age.There exists significant difference betweensystolicand diastolic blood pressure among different age groups(F=51.637,15.995,P<0.05).The average Hb concentration of perimenopausal women in plateau area was(142.74±20.29) g/L.The Hb concentration increases with age and the difference between perimenopausal women among different age groups was significant(F=16.659,P<0.05).The average Hct concentration of perimenopausal women was(40.98±8.34)%,and the difference among age groups was also significant(F=22.998,P<0.05).However, difference of RBC level among different age groups was not statistically significant.Ratios of Hb≥150 g/L samples inside the groups increaseswithage, raio of 40 years-group was 5.13%,50 years-group was 24.71%, 60 years-group was 56.25%.There weree significant differences among three groups(χ^(2)=34.028,P<0.05).Ratio of samples with Hct≥45% is significantly different among age groups(χ^(2)=27.615,P<0.05).Amount of samples with Hb≥190(g/L) of 40 years

关 键 词：高海拔地区 围绝经期女性 女性性激素 血红蛋白 红细胞比容 

分 类 号：R711[医药卫生—妇产科学]