2019-2021年河南省育龄期妇女乙型病毒性肝炎表面抗体血清学调查  

A serological survey of hepatitis B surface antibody among women of childbearing age in Henan province from 2019 to 2021

作　　者：吕宛玉 豆巧华 杜冰会 陈艳萍[3] 李军[1] 丰达星[1,2] 刘倩 孔江南[1,2] 徐瑾 张延炀 赵东阳[1] 郭永豪 LYU Wanyu;DOU Qiaohua;DU Binghui;CHEN Yanping;LI Jun;FENG Daxing;LIU Qian;KONG Jiangnan;XU Jin;ZHANG Yanyang;ZHAO Dongyang;GUO Yonghao(Henan Provincial Center for Disease Control and Prevention,Zhengzhou,Henan 450016,China;Henan Provincial Key Laboratory of Immunomedicine;College of Public Health,Zhengzhou University)

机构地区：[1]河南省疾病预防控制中心,河南郑州450016 [2]河南省免疫预防医学重点实验室 [3]郑州大学公共卫生学院

出　　处：《河南预防医学杂志》2023年第1期56-59,共4页Henan Journal of Preventive Medicine

基　　金：河南省自然科学基金面上项目(222300420466)。

摘　　要：目的 了解河南省育龄期妇女乙型病毒性肝炎(乙肝)表面抗体(HBsAb)阳性率。方法 采用随机抽样的方法,选择河南省18个地市的育龄期(15~49岁)妇女,进行个案调查并采集血标本,用酶联免疫吸附试验定性检测血清中HBsAb。结果 共纳入5 045名调查对象,HBsAb阳性3 138例,阳性率62.20%。HBsAb阳性率最高的省辖市许昌市为74.60%(141/189),最低的安阳市为42.50%(119/280),不同地市间差异有统计学意义(χ^(2)=130.048,P<0.05);农村阳性率为58.57%(1 763/3 010),低于城市67.57%(1 375/2 035),差异具有统计学意义(χ^(2)=41.793,P<0.05);25~29岁阳性率最高,为72.02%(507/704),15~19岁最低,为52.51%(524/998),不同年龄组差异有统计学意义(χ^(2)=89.056,P<0.05);不同职业阳性率医护人员最高,为80.18%(449/560),农民最低,为53.81%(643/1 195),差异具有统计学意义(χ^(2)=187.840,P<0.05);大学及以上阳性率最高,为75.17%(675/898),小学以下最低,为50.00%(16/32),不同受教育程度差异具有统计学意义(χ^(2)=115.110,P<0.05);乙肝疫苗接种剂次不同的人群,阳性率最高的为>3剂次88.52%(102/127),最低的为3剂次59.50%(401/674),差异具有统计学意义(χ^(2)=37.392,P<0.05)。结论 河南省育龄期妇女HBsAb阳性率虽然较高,但依然存在区域以及人群不均衡,应针对薄弱地区和人群加强乙肝疫苗接种和健康教育。Objective To understand the positive rate of Hepatitis B surface Antibody (HBsAb) among women of childbearing age in Henan province.Methods Women of childbearing age (15-49 years old) from 18 cities in Henan province were selected by random sampling method.The cases were investigated and blood samples were collected for qualitative detection of HBsAb in serum by enzyme-linked immunosorbent assay (ELISA).Results The positive rate of HBsAb among 5 045 subjects was 62.20%(3 138/5 045).The highest positive rate of HBsAb was 74.60%(141/189)in the city of Xuchang,while the lowest was 42.50%(119/280) in the city of Anyang,and the difference of the positive rate among the cities was statistically significant (χ^(2)=130.048P<0.05).The positive rate in rural area was 58.57%(1 763/3 010),which was lower than that in urban area 67.57%(1 375/2 035),and the difference was statistically significant (χ^(2)=41.793,P<0.05).The highest positive rate was 72.02%(507/704) in the group of 25-29 years old,while the lowest was 52.51%(524/998) in the group of 15-19 years old,and the difference among the age group was statistically significant (χ^(2)=89.056,P<0.05).Among different occupational groups,the positive rate in medical staffs was highest (80.18%,449/560),while farmers had the lowest (53.81%,643/1 195),with the statistically significant difference(χ^(2)=187.840,P<0.05).The positive rate in the group with college education was highest (75.17%,675/898),while illiterates had the lowest (50.00%,16/32),and the difference was statistically significant (χ^(2)=115.110,P<0.05).Among different groups with different hepatitis B vaccination history,the positive rate among the group with>3 doses was highest (88.52%,102/127),while the group with 3 doses had the lowest (59.50%,401/674),and the difference was statistically significant (χ^(2)=37.392,P<0.05).Conclusions The positive rate of HBsAb were high among women of childbearing age in Henan province,whereas with regional and demographic disparities.hepatitis B vaccination and health edu

关 键 词：乙肝 乙肝表面抗体 育龄期妇女 阳性率 

分 类 号：R512.6[医药卫生—内科学]