RNA m^(6)A甲基化调控免疫稳态的机制及研究进展  

Progress on N^(6)-methyladenosine regulation of immune homeostasis

作　　者：宗鑫 付杰 靳明亮 汪以真[1,2,3] ZONG Xin;FU Jie;JIN MingLiang;WANG YiZhen(College of Animal Sciences,Zhejiang University,Hangzhou 310058,China;Key Laboratory of Molecular Animal Nutrition of Ministry of Education,Hangzhou 310058,China;Zhejiang Provincial Laboratory of Feed and Animal Nutrition,Hangzhou 310058,China)

机构地区：[1]浙江大学动物科学学院,杭州310058 [2]动物分子营养学教育部重点实验室,杭州310058 [3]浙江省饲料及动物营养重点实验室,杭州310058

出　　处：《中国科学：生命科学》2023年第3期334-346,共13页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:32002185,31630075)资助。

摘　　要：免疫系统的运行依赖于对基因表达的严格调控.近些年来,发现RNA修饰N6-甲基腺苷(m^(6)A)在维持机体免疫稳态过程中发挥着重要作用.本综述在介绍RNA m^(6)A修饰及其研究方法的基础上,总结了RNA m^(6)A调控免疫稳态的机制及研究进展,包括免疫识别、抗病毒感染、抗细菌感染、获得性免疫应答以及肿瘤免疫.此外,讨论了该领域当前的一些挑战,并展望了m^(6)A甲基化修饰与免疫稳态相关研究的未来方向.The function of the immune system relies on the strict regulation of gene expression.Recent studies have identified that RNA-modified N6-Methyladenosine(m^(6)A)plays an important role in maintaining immune homeostasis.Here,based on previous research methods for RNA m^(6)A methylation,we review the current research progress of the effect of RNA m^(6)A regulation on immune homeostasis,such as immune recognition,antiviral infection,antibacterial infection,adaptive immune response,and tumor immunity.In addition,we discuss some of the current challenges in this field and suggest the future direction of research related to m^(6)A methylation modification and immune homeostasis.

关 键 词：表观遗传 RNA m^(6)A甲基化 免疫调控 免疫稳态 

分 类 号：R392[医药卫生—免疫学]