肝脏类器官芯片在生物医学中的研究进展  

Research progress of liver organoid chip in biomedicine

作　　者：苏军 公一 周佳菁[1] 徐祎春 韩峻松[1] SU Jun;GONG Yi;ZHOU Jia-Jing;XU Yi-Chun;HAN Jun-Song(Shanghai Biochip Co.,Ltd.,National Engineering Center for Biochip at Shanghai,Shanghai 201203,China;Tongji Hospital Affliated to Tongji University,Shanghai 200092,China)

机构地区：[1]上海生物芯片有限公司生物芯片(上海)国家工程研究中心,上海201203 [2]同济大学附属同济医院,上海200092

出　　处：《生命科学》2023年第2期241-249,共9页Chinese Bulletin of Life Sciences

基　　金：上海市“科技创新行动计划”科学仪器领域项目(22142202700)。

摘　　要：肝脏类器官芯片是一种基于三维培养并搭配微流控系统的特殊芯片。肝脏类器官可依托芯片技术,在体外构建出具有三维结构的人体肝脏生理微系统。该文概述了肝脏类器官芯片在生物医学领域的最新研究成果,归纳总结包括三维肝细胞芯片、肝血窦芯片和肝小叶芯片在内的不同类型的肝脏类器官芯片特点,分析肝脏类器官芯片领域发展面临的诸多机遇和挑战,展望了肝脏类器官芯片未来的发展方向。肝脏类器官芯片技术将为人类疾病和健康领域开创新的研究途径。The liver organoid chip is a special chip based on three-dimensional cell culture,regulating the fluids flow by microfluidic system.In vitro,construction of liver organoid needs to rely on liver organoid chip technology to build three-dimensional physiological microsystem of human liver.Here,we reviewed the latest studies of liver organoid chip in the biomedical field,and summarized the characteristics of different types of liver organoid chips including three-dimensional hepatocyte chip,hepatic sinusoid chip and hepatic lobule chip.Besides,we pointed out opportunities and challenges of liver organoid chip development,and prospected the following development direction of liver organoid chip.Liver organoid chip technology will provide new research approachs in human disease and health field.

关 键 词：肝脏类器官 肝脏类器官芯片 三维肝细胞芯片 肝血窦芯片 肝小叶芯片 

分 类 号：R318.14[医药卫生—生物医学工程] R575[医药卫生—基础医学]