生物衰老的主要分子机制概述  

Overview of the Main Molecular Mechanisms of Biological Aging

作　　者：张维 王红芳[1] 胥保华[1] ZHANG Wei;WANG Hongfang;XU Baohua(College of Animal Science and Technology,Shandong Agricultural University,Shandong Taian 271018,China)

机构地区：[1]山东农业大学动物科技学院,山东泰安271018

出　　处：《生物技术进展》2023年第2期228-233,共6页Current Biotechnology

基　　金：国家自然科学基金项目(32272937);国家自然科学基金青年项目(32102607)。

摘　　要：衰老是一种包括生理性衰老和病理性衰老的正常自然规律,与其他生物过程一样,受一些信号通路和分子机制的调控。研究发现调控生物衰老机制的信号通路之间存在相互作用。综述了胰岛素通路、雷帕霉素通路及Sirtuins家族这3种与自噬相关的延缓衰老的经典信号通路,总结了氧化应激、细胞衰老、免疫衰老等影响机体衰老的主要原因及方式,希望在此基础上发现新的互作通路,探索出更多新颖的分子机制和方法以预防、延缓或减轻多种与衰老相关的疾病。Aging is a normal natural law including physical aging and pathological aging.Like other biological processes,it is regulated by some signaling pathways and molecular mechanisms.Through the research on the mechanism of regulating biological aging,it is found that the signaling pathways interact with each other.This paper reviewed three classical signal pathways related to autophagy and delaying aging,including insulin pathway,rapamycin pathway and Sirtuins family,and summarized the main causes and ways of oxidative stress,cell aging and immune aging affecting aging,hoping to discover new interaction pathways and explore more novel molecular mechanisms and methods to prevent,delay or reduce a variety of diseases related to aging.

关 键 词：衰老 信号通路 分子机制 

分 类 号：Q419[生物学—生理学]