乳腺癌术后发生上肢深静脉血栓形成的危险因素分析  

Analysis of risk factors of upper extremity deep venous thrombosis in post-operative patients with breast cancer

作　　者：曹立华 牛振凯 孙岩 CAO Li-hua;NIU Zhen-kai;SUN Yan(Department of Surgery,Binzhou Hospital of Traditional Chinese Medicine,Binzhou 256600,China;Department of Vascular Surgery,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)

机构地区：[1]滨州市中医医院外科,山东滨州256600 [2]山东第一医科大学附属省立医院血管外科,山东济南250021

出　　处：《中国现代普通外科进展》2023年第3期189-193,共5页Chinese Journal of Current Advances in General Surgery

基　　金：山东省中医药科技发展计划(2019-0303);山东省医药卫生科技发展计划(2018WS273)。

摘　　要：目的:探讨乳腺癌患者术后发生上肢深静脉血栓形成的危险因素分析。方法:回顾性分析2014年1月—2021年1月于滨州市中医医院接受手术治疗的105例乳腺癌患者的临床资料,根据术后是否发生上肢深静脉血栓形成分为病例组和对照组,对两组临床资料进行单因素分析,将组间比较差异有统计学意义的因素,代入二元Logistic回归方程,进行独立危险因素检验,筛选乳腺癌患者术后发生上肢深静脉血栓形成的危险因素。结果:两组年龄、合并糖尿病人数、合并高血压人数、中心静脉置管人数、输血人数、手术方式、凝血酶原时间水平、超敏C反应蛋白水平、血栓弹力图R值、K值差异有统计学意义(P<0.05)。Logistic回归结果表明,合并糖尿病、手术方式、中心静脉置管、超敏C反应蛋白(≥50 mg/L)为乳腺癌术后发生上肢深静脉血栓形成的独立危险因素(P<0.05)。结论:合并糖尿病、手术方式、中心静脉置管、超敏C反应蛋白(≥50 mg/L)是乳腺癌术后发生上肢深静脉血栓形成的独立危险因素,临床工作者在评估上肢深静脉血栓形成发生风险时应纳入对上述危险因素的考量。Objective:To investigate the risk factors of risk factors of upper extremity deep venous thrombosis in post-operative patients with breast cancer.Methods:The clinical data of 105 post-operative patients with breast cancer hospitalized in Binzhou Hospital of Traditional Chinese Medicine from Jan 2014 to Jan 2021 were retrospectively analyzed.The patients were divided into case group and control group according to the occurrence of upper extremity deep venous thrombosis.The clinical data was compared and analyzed in a single-factor analysis.The single factors with significant differences between two groups were substituted into binary logistic regression equation for independent risk factor test.Results:Age,number of patients with diabetic mellitus,number of patients with hypertension,number of patients with central venous cannulation,surgical approach,number of patients received blood transfusion,level of prothrombin time and high sensitivity C-reactive protein,level of R value and K value of thromboelastogram between two groups were statistically significant differences(P<0.05).Logistic regression showed that number of patients with diabetic mellitus,number of patients with central venous cannulation,surgical approach and level of high sensitivity C-reactive protein(≥50 mg/L)were the independent risk factors of upper extremity deep venous thrombosis in post-operative patients with breast cancer.Conclusion:Diabetic mellitus,central venous cannulation,surgical approach and level of high sensitivity C-reactive protein(≥50 mg/L)were the independent risk factors of upper extremity deep venous thrombosis in post-operative patients with breast cancer.Clinical practitioners should include consideration of the above risk factors when assessing the risk of upper extremity deep venous thrombosis.

关 键 词：上肢深静脉血栓形成 乳腺肿瘤 危险因素 

分 类 号：R654.4[医药卫生—外科学]