高尿酸血症动物模型研究进展  

Progress of hyperuricemia animal model research

作　　者：王琳 沈嘉艳 谢招虎 秦冬冬 李兆福 马晓惠 吕小满 WANG Lin;SHEN Jiayan;XIE Zhaohu;QIN Dongdong;LI Zhaofu;MA Xiaohui;LYU Xiaoman(Yunnan University of Traditional Chinese Medicine,Kunming 650000,China)

机构地区：[1]云南中医药大学,昆明650000

出　　处：《中国实验动物学报》2023年第1期112-119,共8页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家中医药管理局中医临床研究基地建设项目(国中医药科技函[2018]131号);云南省中医临床医学研究中心项目(202102AA310006);云南省王庆国专家工作站(202005AF150017);国家自然科学基金(8226150978);中医联合面上项目(11370101874);云南省科学技术厅-云南中医药大学应用基础研究联合专项面上项目(202101AG070394);云南省中医联合专项项目(2019FF002(-052))。

摘　　要：随着经济的发展,人们生活方式和饮食结构发生改变,高尿酸血症的临床检出率逐年增加,高尿酸血症是继高血压、糖尿病、高血脂之后的“第四高”,其发病率已趋于年轻化,因此,建立合适的动物模型是研究高尿酸血症发病机制及预防疾病的重要渠道。近年来关于高尿酸血症模型建立的文献较多,笔者对近年相关文献进行了查阅,总结了常见的动物模型并对增加尿酸来源、抑制尿酸酶活性、抑制尿酸排泄及其他造模方法进行了综述。可为研究治疗、预防高尿酸血症相关药物以及模型的构建方法提供参考。With the development of the world economy,people’s lifestyles and dietary structure have changed,and the clinical detection rate of hyperuricemia is increasing year by year.Hyperuricemia has the“fourth highest”incidence after hypertension,diabetes,and hyperlipidemia,and its incidence rate tends to be higher in younger people.Therefore,the establishment of appropriate animal models is an important step in studying the pathogenesis of hyperuricemia and preventing related diseases.In recent years,extensive literature has been published on the establishment of hyperuricemia models.We consulted the relevant literature from recent years and summarized common animal models;we summarized the method for increasing the source of uric acid,inhibiting the activity of uricase,inhibiting the excretion of uric acid,and other modeling method.This paper provides a reference for the study of drugs related to the treatment and prevention of hyperuricemia and method for the construction of hyperuricemia models.

关 键 词：高尿酸血症 动物模型 禽类 啮齿类 

分 类 号：Q95-33[生物学—动物学]