莫沙必利联合通腑活血汤治疗脓毒症胃肠功能障碍的效果及对血清炎性因子的影响  

Effect of Mosapride Combined with Tongfu Huoxue Decoction in the Treatment of Sepsis Gastrointestinal Dysfunction the Impacton Serum Inflammatory Factors

作　　者：刘萍 刘玉月 辛可可[1] 张静毅 左少飞 尹路 孙俊丽[1] LIU Ping;LIU Yuyue;XIN Keke;ZHANG Jingyi;ZUO Shaofei;YIN Lu;SUN Junli(Comprehensive ICU,Luoyang Central Hospital,Luoyang 471000,China)

机构地区：[1]洛阳市中心医院综合ICU,河南洛阳471000

出　　处：《临床医学工程》2023年第3期343-344,共2页Clinical Medicine & Engineering

摘　　要：目的探讨莫沙必利联合通腑活血汤治疗脓毒症胃肠功能障碍的效果及对血清炎性因子的影响。方法选取2020年1月至2022年4月我院收治的80例脓毒症胃肠功能障碍患者,按照奇偶性原则分为对照组(n=40)和观察组(n=40)。对照组给予莫沙必利治疗,观察组给予莫沙必利联合通腑活血汤治疗。比较两组的胃肠功能障碍程度、腹腔压力、肠鸣音次数及炎性因子水平。结果治疗后,观察组胃肠功能障碍改善程度优于对照组(P<0.05)。治疗后,观察组腹腔压力低于对照组,肠鸣音次数高于对照组(P<0.05)。治疗后,观察组的TNF-α、IL-6、PCT水平均低于对照组(P<0.05)。结论莫沙必利联合通腑活血汤治疗脓毒症胃肠功能障碍的效果显著,可有效促进患者胃肠功能恢复,降低炎性因子水平。Objective To explore the effect of mosapride combined with Tongfu Huoxue decoction in the treatment of sepsis gastrointestinal dysfunction and the impact on serum inflammatory factors.Methods 80 patients with sepsis gastrointestinal dysfunction admitted to our hospital from January 2020 to April 2022 were divided into control group(n=40)and observation group(n=40)according to the parity principle.The control group was treated with mosapride,and the observation group was treated with mosapride combined with Tongfu Huoxue decoction.The gastrointestinal dysfunction degree,abdominal pressure,number of bowel sounds and levels of inflammatory factors were compared between the two groups.Results After treatment,the improvement of gastrointestinal dysfunction in the observation group was better than that in the control group(P<0.05).After treatment,the abdominal pressure of the observation group was lower than that of the control group,and the number of bowel sounds was higher than that of the control group(P<0.05).After treatment,the TNF-α,IL-6 and PCT levels of the observation group were lower than those of the control group(P<0.05).Conclusions Mosapride combined with Tongfu Huoxue decoction in the treatment of sepsis gastrointestinal dysfunction has significant effective in the treatment of gastrointestinal dysfunction in sepsis,which can effectively promote the recovery of gastrointestinal function and reduce the level of inflammatory factors.

关 键 词：莫沙必利 通腑活血汤 脓毒症 胃肠功能障碍 

分 类 号：R459.7[医药卫生—急诊医学]