器官芯片技术在药物毒理学领域的研究现状及应用前景  

Research status and application prospect of organ-on-chip technology in the field of drug toxicology

作　　者：张文庆 王璇璇 黄安琪 谢地 辛梦茹 刘薇芝[1] 胡汉昆[1,2,3] ZHANG Wenqing;WANG Xuanxuan;HUANG Anqi;XIE Di;XIN Mengru;LIU Weizhi;HU Hankun(Department of Pharmacy,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei Province,China;Hubei Micro-explore Innovative Pharmaceutical Research Co.,Ltd.,Wuhan 430074,Hubei Province,China;Suzhou Organ-on-a-Chip System Science and Technology Co.,Ltd.,Suzhou 215000,Jiangsu Province,China)

机构地区：[1]武汉大学中南医院药学部,湖北武汉430071 [2]湖北精微格致创新医药研究有限公司,湖北武汉430074 [3]苏州欧奇普系统科技有限公司,江苏苏州215000

出　　处：《世界临床药物》2023年第1期83-89,共7页World Clinical Drug

基　　金：基于开放许可交易的湖北省生物医药产业成果转化机制研究(CXRK2022000184);中国药学会医院药学专业委员会重点科研项目(CPA-Z05-ZC-2022-002);湖北省揭榜制项目(2022BEC035)。

摘　　要：传统的药物毒理学研究多以实验动物为研究对象,但动物试验易受多种因素影响,难以完全模拟药物在人体内的毒性反应,在预测药物毒性方面存在缺乏灵敏度和特异性等问题。器官芯片技术通过构建心、肝及肾脏等器官芯片,开展体外毒理学评价,在药物毒理学领域日益受到关注。文章对国内外器官芯片技术在药物毒理学领域的研究现状、存在的挑战及应用前景进行综述,为该技术的发展和应用提供参考。Traditional toxicological studies of drugs mostly focused on experimental animals.However,animal experiments were susceptible to many factors,and it was difficult to completely simulate the toxic reaction of drugs in human body,and there was a lack of sensitivity and specificity to predict drug toxicity.Organ-on-chip technology had attracted increasing attention by constructing heart,liver,kidney and other organ chips to carry out toxicological evaluation in vitro.In this paper,the research status,challenges and application prospects of the new technology in drug toxicological evaluation were reviewed,in order to provide reference for the development and application of this technology.

关 键 词：器官芯片 药物毒理学 在线检测 标准化 

分 类 号：TN492[电子电信—微电子学与固体电子学] R318[医药卫生—生物医学工程]