靶向哮喘气道上皮研究进展  

Research progress of targeting bronchial epithelium in asthma

作　　者：黄俊文 陈颖 蔡绍曦[1] 赵海金[1] Huang Junwen;Chen Ying;Cai Shaoxi;Zhao Haijin(Chronic Airways Diseases Laboratory,Department of Respiratory and Critical Care Medicine,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院呼吸与危重症医学科慢性气道疾病实验室,广州510515

出　　处：《结核与肺部疾病杂志》2023年第2期153-157,共5页Journal of Tuberculosis and Lung Disease

基　　金：国家自然科学基金(81900027,82070030);广东省自然科学基金(2022A1515012064,2023A1515010406)。

摘　　要：哮喘是一种遗传和环境因素共同作用的异质性疾病,气道上皮损伤是哮喘患者常见的气道病理改变。气道上皮的物理屏障功能和免疫调节功能共同应对病毒、过敏原及大气污染物的刺激和损伤后修复,并在哮喘气道炎症、气道高反应性及气道重塑中发挥重要作用。近年来,针对气道上皮的靶向疗法已经显示出临床治疗价值,有可能成为哮喘,尤其是重度哮喘新的干预靶点。本文将重点探讨气道上皮在哮喘发病中的作用及靶向哮喘气道上皮的治疗策略。Asthma is a heterogeneous disease affected by both heredity and environment.Airway epithelial injury is a common pathological change in asthma.The physical barrier function and immunomodulatory function of airway epithelium cooperatively respond to the stimulation and post-injury repair of viruses,allergens and air pollutants,and play an important role in airway inflammation,airway hyper-responsiveness and airway remodeling.In recent years,targeted therapy for bronchial epithelium had shown clinical value and became a potential new intervention target for asthma,especially for severe asthma.This article will focus on the role of airway epithelium in the pathogenesis of asthma and the treatment strategy targeting the airway epithelium of asthma.

关 键 词：哮喘 病理学 临床 上皮 综述文献(主题) 

分 类 号：R562[医药卫生—呼吸系统]