神经酰胺及神经酰胺合成酶在哮喘中的作用  

The role of ceramide and ceramide synthetase in asthma

作　　者：胡亭亭 常春[1] Hu Tingting;Chang Chun(Department of Respiratory and Critical Care Medicine,Third Hospital of Peking University,Beijing 100191,China)

机构地区：[1]北京大学第三医院呼吸与危重症医学科,北京100191

出　　处：《结核与肺部疾病杂志》2023年第2期164-168,共5页Journal of Tuberculosis and Lung Disease

摘　　要：神经酰胺是鞘脂代谢的中心,也是一种重要的信号分子,参与细胞分化、增殖、凋亡和迁移等多种生物功能。神经酰胺合成酶介导神经酰胺的合成。哮喘是一种以气流阻塞、气道高反应性和肺部炎症为特征的慢性气道疾病,极大地影响了患者的生活质量,是重要的公共卫生问题。研究表明,神经酰胺在哮喘的病理生理发展中发挥重要作用。本文重点讨论神经酰胺对参与哮喘发病的多种细胞的影响,以及不同种类神经酰胺作用的差异性,以期为人们更好地了解哮喘及寻找哮喘潜在治疗靶点提供理论基础。Ceramide is the center of sphingolipids metabolism and is an important signal molecule participates in many biological functions such as cell differentiation,proliferation,apoptosis and migration.Synthesis is mediated by ceramide synthetase.Asthma is a chronic airway disease characterized by airflow obstruction,airway hyper-responsiveness and lung inflammation,which greatly affects the quality of life and is an important public health problem.Studies have shown that ceramides play an important role in the pathophysiological development of asthma.This article focuses on the effects of ceramides on various cells involved in the pathogenesis of asthma and the differences in the effects of different ceramides,to provide a theoretical basis for better understanding of asthma and finding potential therapeutic targets for asthma.

关 键 词：哮喘 神经酰胺类 综述文献(主题) 

分 类 号：R256.12[医药卫生—中医内科学]