肠内营养联合双歧杆菌三联活菌胶囊辅助治疗重症肺炎的临床研究  

Efficacy of enteral nutrition combined bifidobacterium-triple viable capsules in auxiliary treatment of severe pneumonia

作　　者：迟永生 胡北平[2] 王欣燕 季小炜 汪百飞 CHI Yongsheng;HU Beiping;WANG Xinyan;JI Xiaowei;WANG Baifei(Department of Critical Care Medicine,Huzhou Hospital of Traditional Chinese Medicine,Zhejiang Chinese Medical University,Huzhou 313000,China;不详)

机构地区：[1]浙江中医药大学附属湖州中医院重症医学科,313000 [2]湖州市中心医院重症医学科 [3]浙江中医药大学附属湖州中医院消化科

出　　处：《浙江医学》2023年第5期523-526,共4页Zhejiang Medical Journal

基　　金：湖州市科技计划项目(2019GYB14)。

摘　　要：目的 探讨肠内营养联合双歧杆菌三联活菌胶囊辅助治疗重症肺炎的效果,及对患者营养状态和血清炎症因子的影响。方法 选取2017年1月至2021年12月湖州市中医院及湖州市中心医院收治的重症肺炎患者120例。两组患者入院后均接受常规治疗。其中60例对照组患者在常规治疗的基础上采用肠内营养治疗,60例观察组患者采用肠内营养联合双歧杆菌三联活菌胶囊治疗。两组患者治疗疗程均为2周。观察并比较两组患者疗效,治疗前后急性生理与慢性健康评估(APACHE II)评分、肺炎严重指数(PSI)、营养状态指标和血清炎症因子变化。结果 观察组患者治疗总有效率高于对照组(93.33%比78.33%,P<0.05)。治疗后,两组患者APACHE II评分、PSI均较治疗前降低(均P<0.05),且观察组低于对照组(均P<0.05)。治疗后,两组患者Hb、前白蛋白和白蛋白水平均较治疗前升高(均P<0.05),且观察组高于对照组(均P<0.05)。治疗后,两组患者IL-6、CRP和降钙素原水平均较治疗前降低(均P<0.05),且观察组低于对照组(均P<0.05)。结论 肠内营养联合双歧杆菌三联活菌胶囊辅助治疗重症肺炎患者效果显著,可改善患者营养状态,减轻患者炎症反应。Objective To investigate the efficacy of enteral nutrition combined with bifidobacterium-triple viable capsule in the auxiliary treatment of severe pneumonia.Methods A total of 120 patients with severe pneumonia admitted to Huzhou Hospital of Traditional Chinese Medicine and Huzhou Central Hospital from January 2017 to December 2021 were divided into two groups with 60 cases in each group.Patients in both groups received routine treatment after admission;in addition,patients in the control group were given enteral nutrition for auxiliary treatment,while patients in study group were given enteral nutrition combined with bifidobacterium capsules.The treatment course was 2 weeks.The treatment efficacy,acute physiological and chronic health assessment(APACHE II)score,pneumonia severity index(PSI),nutritional status index and serum inflammatory factors were observed before and after treatment,and compared between the two groups.Results The total effective rate of the study group was higher than that of control group(93.33%vs.78.33%,P<0.05).After treatment,APACHE II scores and PSI scores in 2 groups were lower than those before treatment(all P<0.05),and the scores of study group were lower than those of control group(all P<0.05).After treatment,the levels of Hb,prealbumin and albumin in 2 groups were higher than those before treatment in both groups(all P<0.05),and the above indicators in study group were higher than those in the control group(all P<0.05).After treatment,IL-6,CRP and calcitonin levels in 2 groups were lower than those before treatment(all P<0.05),and the levels in study group were lower than those in the control group(all P<0.05).Conclusion Enteral nutrition combined with bifidobacterium-triple live capsule has a significant effect in auxiliary treatment for patients with severe pneumonia,which can improve the nutritional status and reduce the inflammatory response of patients.

关 键 词：肠内营养 双歧杆菌三联活菌胶囊 重症肺炎 疗效 营养状态 炎症因子 

分 类 号：R563.1[医药卫生—呼吸系统]