同型半胱氨酸的传感检测研究与应用  

Research and application on sensing detection of homocysteine

作　　者：周宁涛 肖国强 张慢乐 袁俊[1] 吴玲[1] 肖忠良[1] 于冬宏 曹忠[1] Zhou Ning-tao;Xiao Guo-qiang;Zhang Man-le;Yuan Jun;Wu Ling;Xiao Zhong-liang;Yu Dong-hong;Cao Zhong(Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation&Hunan Provincial Key Laboratory of Cytochemistry,School of Chemistry and Chemical Engineering,Changsha University of Science and Technology,Changsha 410114,China;Chongqing Academy of Metrology and Quality Inspection,Chongqing 401123,China;Department of Chemistry and Bioscience,Aalborg University,DK-9220 Aalborg,Denmark)

机构地区：[1]长沙理工大学化学化工学院,电力与交通材料保护湖南省重点实验室,细胞化学湖南省重点实验室,湖南长沙410114 [2]重庆市计量质量检测研究院,重庆401123 [3]奥尔堡大学化学与生物科学系,丹麦奥尔堡DK-9220

出　　处：《化学传感器》2021年第3期23-31,共9页Chemical Sensors

基　　金：国家自然科学基金(31527803);湖南省自然科学基金(2020JJ40559);湖南省教育厅科学研究项目(21A0182,21C0195);长沙理工大学大学生创新训练计划(No.2022-0165)项目资助。

摘　　要：同型半胱氨酸(Hcy)是一种含巯基的非必需氨基酸,在蛋白质合成、细胞代谢和氧化应激调节等多种生理和病理过程中不可或缺,与高血压、心血管疾病、帕金森病和慢性肾炎等疾病的发生和发展密切相关。因此,开发用于检测生物体中Hcy的新方法对于上述疾病的预防与治疗有重要意义。该文主要介绍了近年来Hcy的检测方法,重点阐述了电化学、光化学传感界面的构建及其材料,并进行了分类与归纳阐述。Homocysteine(Hcy)is a non-essential amino acid containing thiol,which is indispensable in a variety of physiological and pathological processes such as protein synthesis,cell metabolism and oxidative stress regulation,and is closely related to the occurrence and development of diseases such as hypertension,cardiovascular disease,Parkinson's disease,and chronic nephritis.Therefore,the development of new methods for detecting Hcy in organisms is of great significance for the prevention and treatment of the above diseases.This article mainly introduces the detection methods of Hcy in recent years,focusing on the construction of electrochemical and photochemical sensing interfaces and their materials,and classifying and summarizing their related key points.

关 键 词：同型半胱氨酸 光化学 电化学 传感材料 应用 

分 类 号：R313[医药卫生—基础医学] TP212[自动化与计算机技术—检测技术与自动化装置]