健脾化痰祛湿法联合针刺周期疗法治疗肥胖型多囊卵巢综合征的疗效观察  

Efficacy of Invigorating Spleen,Resolving Phlegm and Removing Dampness Combined with Acupuncture Cycle Therapy on Obese Polycystic Ovary Syndrome

作　　者：翟璇 王爽 牛凤鹤 李世玲[1] ZHAI Xuan;WANG Shuang;NIU Feng-he;LI Shi-ling(Department of Gynecology of Traditional Chinese Medicine,Nanyang Second General Hospital,Nanyang Henan 473000)

机构地区：[1]南阳市第二人民医院中医妇科,河南南阳473000

出　　处：《世界中西医结合杂志》2023年第2期305-308,313,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河南省医学科技攻关计划项目(LHGJ20200898);2018年南阳市科技发展计划项目(KJGG2018129)。

摘　　要：目的观察肥胖型多囊卵巢综合征(Polycystic ovarian syndrome,PCOS)患者应用健脾化痰祛湿法联合针刺周期疗法的临床疗效。方法选取2019年6月—2021年6月期间在南阳市第二人民医院中医妇科就诊的肥胖型PCOS患者100例,采用简单随机化法分对照组和试验组,每组各50例。对照组采用常规治疗,试验组常规治疗+健脾化痰祛湿法联合针刺周期疗法。治疗3个月后,观察比较两组患者临床疗效,治疗前后体质量指数(Body mass index,BMI)、腰臀比(Waist hip ratio,WHR)、子宫内膜容受性[子宫内膜厚度、子宫动脉血流搏动指数(Pulsatility index,PI)和子宫动脉阻力指数(Resistance index,RI)]和糖代谢指标[糖化血红蛋白(HbAlc)、空腹胰岛素(Fasting insulin,FINS)和胰岛素抵抗指数(Homeostasis model assessment-insulin resistance,HOMA-IR)]、脂肪代谢因子[脂联素(Adiponectin,APN)、廋素(Leptin,LEP)]水平。结果治疗后试验组总有效率为90.00%(45/50)明显高于对照组74.00%(37/50),差异有统计学意义(P<0.05)。治疗后两组患者BMI指数及WHR比值均较治疗前降低,差异有统计学意义(P<0.05);且试验组BMI指数及WHR比值均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者子宫内膜厚度均较治疗前增厚、RI指数均较治疗前降低,差异有统计学意义(P<0.05);且试验组子宫内膜厚度较对照组增厚、RI指数较对照组降低,差异有统计学意义(P<0.05)。治疗后两组患者HbAlc、FINS及HOMA-IR水平均较治疗前降低,差异有统计学意义(P<0.05);且试验组HbAlc、FINS及HOMA-IR水平均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者APN、LEP水平均较治疗前降低,差异有统计学意义(P<0.05);且试验组APN、LEP水平均较对照组降低,差异有统计学意义(P<0.05)。结论应用健脾化痰祛湿法联合针刺周期疗法治疗肥胖型PCOS可提高疗效,并能改善患者子宫内膜容受性和糖脂代谢因�Objective To explore the clinical efficacy of invigorating spleen,resolving phlegm and removing dampness combined with acupuncture cycle therapy in obese patients with polycystic ovary syndrome(PCOS).Methods A total of 100 obese patients with PCOS treated in the Department of Gynecology of Traditional Chinese Medicine,Nanyang Second General Hospital from June 2019 to June 2021 were included.They were divided into a control group and an experimental group by simple randomization,with 50 in each group.The control group received conventional treatment,while the experimental group received conventional treatment+spleen-invigorating,phlegm-resolving and dampness-removing treatment combined with acupuncture cycle therapy.After 3 months of treatment,the clinical efficacy of the two groups,and the changes of body mass index(BMI),waist-to-hip ratio(WHR),endometrial receptivity[endometrial thickness,pulsatility index(PI),resistance index(RI)]and glucose and lipid metabolism-related factors[hemoglobin Alc(HbAlc),fasting insulin(FINS),homeostasis model assessment-insulin resistance(HOMA-IR),adiponectin(APN),leptin(LEP)]before and after treatment were compared.Results The total effective rate of the experimental group was 90.00%(45/50)higher than 74.00%(37/50)of the control group(P<0.05).After treatment,BMI,WHR,RI and the levels of HbAlc,FINS,HOMA-IR,APN and LEP were decreased in both groups while the endometrial thickness was increased compared withthose before treatment(all P<0.05),and the experimental group had more decreases and increase than the control group(all P<0.05).Conclusion The method of invigorating spleen,resolving phlegm and removing dampness combined with acupuncture cycle therapy enhances the curative efficacy of obese patients with PCOS,and improves the endometrial receptivity and glucose and lipid metabolism factors.

关 键 词：肥胖 多囊卵巢综合征 健脾化痰祛湿法 针刺 

分 类 号：R711.75[医药卫生—妇产科学]