血塞通软胶囊对不稳定性心绞痛患者血管内皮功能及炎性因子的影响  

Effect of Xuesaitong Soft Capsules on Vascular Endothelial Function and Inflammatory Factors in Patients with Unstable Angina Pectoris

作　　者：范红玲[1] 张曼宇 FAN Hong-ling;ZHANG Man-yu(Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou Henan 450003;Henan University of Chinese medicine,Zhengzhou Henan 450046)

机构地区：[1]河南省中医院,河南郑州450003 [2]河南中医药大学,河南郑州450046

出　　处：《世界中西医结合杂志》2023年第2期328-332,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河南省中医药科学研究专项课题(2019JDZX002)。

摘　　要：目的研究血塞通软胶囊对不稳定性心绞痛患者血管内皮功能及炎性因子相关指标的影响。方法选取2020年1月—2021年3月期间河南省中医院心病科收治的心血瘀阻证不稳定性心绞痛住院患者176例,按随机数字表法分为试验组和对照组,每组各88例。两组患者均采取西医常规治疗,必要情况下可含服硝酸甘油片,试验组除常规西药外同时服用血塞通软胶囊。治疗15 d后,观察比较两组患者临床疗效,治疗前后血管内皮功能指标[肱动脉血流介导的血管舒张功能(Flow-mediated dilation,FMD)、单核细胞趋化因子(Monocyte chemotactic protein 1,MCP-1)、可溶性血管细胞间黏附分子(Soluble vascular cell adhesion molecule-1,sVCAM-1)、内皮素-1(Endothelin-1,ET-1)、一氧化氮(Nitric Oxide,NO)]以及血清炎性因子[白介素6(Interleukin 6,IL-6)、白介素10(Interleukin 10,IL-10)、高敏C反应蛋白(High-sensitivity C-reactive protein,hs-CRP)、肿瘤坏死因子α(Tumor necrosis factor alpha,TNF-α)、血清可溶性CD40配体(Soluble CD40 ligand,sCD40L)]水平。结果治疗后试验组总有效率92.05%(81/88)明显优于对照组总80.68%(71/88),差异有统计学意义(P<0.05)。治疗后试验组中医证候疗效总有效率93.18%(82/88)明显优于对照组78.55%(70/88),差异有统计学意义(P<0.01)。治疗后两组患者血清IL-6、hs-CRP、sCD40L及TNF-α水平均较治疗前降低,IL-10水平均较治疗前升高,差异有统计学意义(P<0.05);且试验组血清IL-6、hs-CRP、sCD40L及TNF-α水平低于对照组,IL-10水平明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者ET-1、MCP-1、sVCAM-1水平均较治疗前降低,NO、FMD水平均较治疗前升高,差异有统计学意义(P<0.05);且试验组血清ET-1、MCP-1、sVCAM-1水平低于对照组,NO、FMD水平高于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论血塞通软胶囊对于�Objective To study the effect of Xuesaitong Soft Capsules on vascular endothelial function and related inflammatory factors in patients with unstable angina pectoris(UAP).Methods A total of 176 UAP patients with heart blood stasis syndrome admitted to the Department of Cardiology,Henan Province Hospital of Traditional Chinese Medicine from January 2020 to March 2021 were included and randomly divided into a treatment group(n=88)and a control group(n=88)according to the random number table method.All patients were treated with conventional western medicine,as well as nitroglycerin tablets if necessary,while those in the treatment group received additional Xuesaitong Soft Capsules.After 15 days of treatment,the clinical efficacy of the two groups was observed,and vascular endothelial function indexes[flow-mediated dilation(FMD),monocyte chemotactic protein 1(MCP-1),soluble vascular cell adhesion molecule-1(sVCAM-1),endothelin-1(ET-1),and nitric oxide(NO)],and serum inflammatory factors[interleukin 6(IL-6),interleukin 10(IL-10),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),and soluble CD40 ligand(sCD40L)]before and after treatment were compared between the two groups.Results After treatment,the total effective rate of the treatment group was 92.05%(81/88),higher than 80.68%(71/88)in the control group(P<0.05).After treatment,the total effective rate of TCM syndrome in the treatment group was 93.18%(82/88),higher than 78.55%(70/88)in the control group(P<0.01).After treatment,serum levels of IL-6,hs-CRP,sCD40L,and TNF-αin the two groups were lower and IL-10 levels were higher than those before treatment(P<0.05).The serum levels of IL-6,hs-CRP,sCD40L,and TNF-αin the treatment groups were lower and IL-10 level was higher than those in the control group(P<0.05).After treatment,the levels of ET-1,MCP-1,and sVCAM-1 in the two groups were lower and the levels of NO and FMD were higher than those before treatment(P<0.05).The levels of ET-1,MCP-1,and sVCAM-1 in the treatment group were lower an

关 键 词：心血瘀阻证 不稳定性心绞痛 血塞通软胶囊 血管内皮功能 炎性因子 

分 类 号：R541.4[医药卫生—心血管疾病]