槲皮素对母胎界面免疫调节的影响  

Effects of quercetin on immune regulation at the maternal-fetal interface

作　　者：傅祝婧 田野[2] 周旋乐 兰慧珍 吴双钰 楼毅云[1] FU Zhujing;TIAN Ye;ZHOU Xuanle;LAN Huizhen;WU Shuangyu;LOU Yiyun(Department of TCM Gynecology,Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University,Hangzhou 310007,China;The Third Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学附属杭州市中医院中医妇科,浙江杭州310007 [2]浙江中医药大学第三临床医学院,浙江杭州310053

出　　处：《浙江大学学报（医学版）》2023年第1期68-76,共9页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金(81801475);浙江省公益技术应用研究计划(LGF22H270021);浙江省卫生健康科技计划(2022RC232);浙江省中医药科技计划(2020ZA074,2022ZA111);浙江省医坛新秀培养项目(浙卫办[2020]18号)。

摘　　要：母胎界面免疫失衡与不良妊娠结局密切相关,是生殖领域亟待解决的热点问题之一。随着中医药在生殖领域中的应用,发现槲皮素在菟丝子、桑寄生等常用补肾中药中含量丰富,可起到一定的妊娠保护作用。作为常见的黄酮类物质,槲皮素具有强大的抗炎、抗氧化、类雌激素等作用,可调节母胎界面免疫细胞(如蜕膜自然杀伤细胞、蜕膜巨噬细胞、T细胞、树突状细胞及髓源性抑制细胞)、绒毛外滋养层细胞及蜕膜基质细胞的功能及各细胞因子活性,通过减弱细胞毒性、减少组织细胞过度凋亡、抑制过度炎症反应等维持母胎免疫动态平衡。本文阐述了槲皮素对母胎界面各组成成分免疫调节过程中的作用及分子机制,以期为复发性流产等不良妊娠结局的治疗提供思路。The imbalance of immune homeostasis at the maternal-fetal interface is closely related to adverse pregnancy outcomes,so it has become one of the hot research topics in the reproductive field.Quercetin is rich in common TCM kidney-tonifying herbs such as dodder and lorathlorace,and has shown pregnancy protection function.As a common flavonoid,quercetin has powerful anti-inflammatory,antioxidant,estrogenlike effects;and it can regulate the functions of maternal-fetal interface immune cells(such as decidual natural killer cells,decidual macrophages,T cells,dendritic cells and myeloid-derived suppressor cells),exovillous trophoblast cells,decidual stromal cells,and the activities of their cytokines.Quercetin maintains the dynamic balance of maternal and fetal immunity by attenuating cytotoxicity,reducing excessive apoptosis of the tissue cells and inhibiting excessive inflammatory reactions.In this article,the role and molecular mechanism of quercetin in the immunomodulatory process of the maternal and fetal interface are reviewed to provide reference for the treatment of recurrent spontaneous abortion and other adverse pregnancy outcomes.

关 键 词：槲皮素 母胎界面 蜕膜免疫细胞 滋养层细胞 蜕膜基质细胞 母胎免疫耐受 分子机制 综述 

分 类 号：R9[医药卫生—药学] R714.14