无氘代核磁实验鉴别喹诺酮类抗生素  

Identification of Quinolone Antibiotics by No-D NMR

作　　者：黄艳萍 Huang Yanping(Center of Engineering Experimental Teaching,School of Chemical Engineering,Sichuan University,Chengdu 610064,China)

机构地区：[1]四川大学化学工程学院,工程实验教学中心,四川成都610064

出　　处：《山东化工》2023年第2期39-41,44,共4页Shandong Chemical Industry

摘　　要：核磁共振技术是制药领域中一种重要的研究手段。在没有合适的氘代溶剂选择的情况下,可选择无氘代核磁共振技术。将无氘代核磁共振技术引入制药工程专业本科专业实验教学,充分发挥核磁共振波谱仪在制药专业实验教学中支撑作用。通过分组预先查阅资料、确立鉴别方案、进行无氘代核磁共振实验和图谱的对比分析,实现对6种喹诺酮类抗生物的鉴别,有利于提高学生的动手能力、自主学习、思考问题和解决问题的能力。Nuclear magnetic resonance(NMR)technology is an important research method in the pharmaceutical field.In the absence of suitable deuterium solvent,no-deuterated solvent(No-D)NMR technology can be selected.The No-D NMR was introduced into the experimental teaching of pharmaceutical engineering undergraduate,and the supporting role of NMR in the experimental teaching of pharmaceutical engineering was fully played.Through consulting data in advance,establishing identification scheme,conducting No-D NMR experiment and comparative analysis of spectrum,the identification of six quinolones can be realized,which is conducive to improving students'practical ability,autonomous learning,thinking and problem-solving ability.

关 键 词：核磁共振 无氘代 喹诺酮类抗生素 鉴别 实验教学 

分 类 号：O6-33[理学—化学]